ID A0A2K6Q9E0_RHIRO Unreviewed; 986 AA.
AC A0A2K6Q9E0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=NLR family pyrin domain containing 7 {ECO:0000313|Ensembl:ENSRROP00000025388.1};
GN Name=NLRP7 {ECO:0000313|Ensembl:ENSRROP00000025388.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000025388.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000025388.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; A0A2K6Q9E0; -.
DR STRING; 61622.ENSRROP00000025388; -.
DR Ensembl; ENSRROT00000049604.1; ENSRROP00000025388.1; ENSRROG00000036446.1.
DR GeneTree; ENSGT00940000164627; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR GO; GO:0019966; F:interleukin-1 binding; IEA:Ensembl.
DR GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0010955; P:negative regulation of protein processing; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF20; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 7; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 119..429
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 111937 MW; 4F2358EF2DAA7935 CRC64;
FTEAGQVQEI DSPQLGDAED DSELANANCC VRLTSKYFTE AGQVQEIDSP QLGDAEDDSE
LAKPGEKEGR RNSVEKQSLV WKNTFWQGDT DSFHDDVIRR NQRFIPFLNP RTPRKLTPYT
VVLHGPAGVG KTTLAKKCML DWTDCNLSPT ARYAFYLSCK ELSHMGPCSF AELISKDWPE
WQDDIPHILA QAQRILFVVD GLDELKVPPG ALIQDLCGDW EQQKPVPVLL GSLLKRKMLP
KAALLVTTRP RALRDLQLLV QQPIYIRVEG FLEEDRRAYF LRHFGDEDQA MRAFELMRSN
AALFQLGSAP AVCWIVCTTL KLQMEKGEDP APTCLTSTGL FLRFLCSQFP QGAQLRGALR
ALSLLAAQSL WAQMSVLHGE DLERVGVQES DLRPFLDRDI LRQDRVSKGC YSFIHLSFQQ
FLTALFYVLE EEEEEEEDRD GHAWDIGDVQ KLLSEEERLK NPDLIQVGHF LFGLANEKRA
KELEATFGCQ MSPEIKQGLL RCKANLHANK PLSMTELKEV LCCLYESQEE ELAKVVVAPF
KEISINLTNT SEMMHCSFSL KHCRDLEKVS LQVAKGVFLE NYVDFEPDIE FERCTYVSLP
SWAQQDLRSL RLWTDFCSLF SSKSNLKFLE VKQSFLSDSS VRILCDHITR STCHLQKVEI
KNVTPDTAYR DFCLAFIGKK TLTHLTLEGH VEWERTMLLL LCDLLRNHKC NLQYLRLGGH
CATSEQWADF SYVLKANQSL NHLHLSASVL LDEGAKLLYK TMTHPNHFLQ MLSLENCRLT
EASCKDLAAV LVVSQQLTHL CLAKNPIGDT GVKFLCEGLS YPECKLQALV LQQCSITKRG
CRYLSEALQE ACSLTNLDLS LNQIARGMWI LCQALENPNC NLKHLRLWSC SLMPFYCQHL
GSALISNQKL ETLDLGQNHL WKSGIIKLFR VLRQRTGSLK TLRLKTYETN SEIKKLLEEV
KEKNPKLTID CNASGATAPA CCDFFC
//