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Database: UniProt
Entry: A0A2K6Q9E0_RHIRO
LinkDB: A0A2K6Q9E0_RHIRO
Original site: A0A2K6Q9E0_RHIRO 
ID   A0A2K6Q9E0_RHIRO        Unreviewed;       986 AA.
AC   A0A2K6Q9E0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=NLR family pyrin domain containing 7 {ECO:0000313|Ensembl:ENSRROP00000025388.1};
GN   Name=NLRP7 {ECO:0000313|Ensembl:ENSRROP00000025388.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000025388.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000025388.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   AlphaFoldDB; A0A2K6Q9E0; -.
DR   STRING; 61622.ENSRROP00000025388; -.
DR   Ensembl; ENSRROT00000049604.1; ENSRROP00000025388.1; ENSRROG00000036446.1.
DR   GeneTree; ENSGT00940000164627; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR   GO; GO:0019966; F:interleukin-1 binding; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR   GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0010955; P:negative regulation of protein processing; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF20; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM00368; LRR_RI; 7.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          119..429
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  111937 MW;  4F2358EF2DAA7935 CRC64;
     FTEAGQVQEI DSPQLGDAED DSELANANCC VRLTSKYFTE AGQVQEIDSP QLGDAEDDSE
     LAKPGEKEGR RNSVEKQSLV WKNTFWQGDT DSFHDDVIRR NQRFIPFLNP RTPRKLTPYT
     VVLHGPAGVG KTTLAKKCML DWTDCNLSPT ARYAFYLSCK ELSHMGPCSF AELISKDWPE
     WQDDIPHILA QAQRILFVVD GLDELKVPPG ALIQDLCGDW EQQKPVPVLL GSLLKRKMLP
     KAALLVTTRP RALRDLQLLV QQPIYIRVEG FLEEDRRAYF LRHFGDEDQA MRAFELMRSN
     AALFQLGSAP AVCWIVCTTL KLQMEKGEDP APTCLTSTGL FLRFLCSQFP QGAQLRGALR
     ALSLLAAQSL WAQMSVLHGE DLERVGVQES DLRPFLDRDI LRQDRVSKGC YSFIHLSFQQ
     FLTALFYVLE EEEEEEEDRD GHAWDIGDVQ KLLSEEERLK NPDLIQVGHF LFGLANEKRA
     KELEATFGCQ MSPEIKQGLL RCKANLHANK PLSMTELKEV LCCLYESQEE ELAKVVVAPF
     KEISINLTNT SEMMHCSFSL KHCRDLEKVS LQVAKGVFLE NYVDFEPDIE FERCTYVSLP
     SWAQQDLRSL RLWTDFCSLF SSKSNLKFLE VKQSFLSDSS VRILCDHITR STCHLQKVEI
     KNVTPDTAYR DFCLAFIGKK TLTHLTLEGH VEWERTMLLL LCDLLRNHKC NLQYLRLGGH
     CATSEQWADF SYVLKANQSL NHLHLSASVL LDEGAKLLYK TMTHPNHFLQ MLSLENCRLT
     EASCKDLAAV LVVSQQLTHL CLAKNPIGDT GVKFLCEGLS YPECKLQALV LQQCSITKRG
     CRYLSEALQE ACSLTNLDLS LNQIARGMWI LCQALENPNC NLKHLRLWSC SLMPFYCQHL
     GSALISNQKL ETLDLGQNHL WKSGIIKLFR VLRQRTGSLK TLRLKTYETN SEIKKLLEEV
     KEKNPKLTID CNASGATAPA CCDFFC
//
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