ID A0A2K6QCJ8_RHIRO Unreviewed; 2265 AA.
AC A0A2K6QCJ8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Collagen alpha-6(VI) chain {ECO:0000313|Ensembl:ENSRROP00000026508.1};
GN Name=COL6A6 {ECO:0000313|Ensembl:ENSRROP00000026508.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000026508.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000026508.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR STRING; 61622.ENSRROP00000026508; -.
DR Ensembl; ENSRROT00000050757.1; ENSRROP00000026508.1; ENSRROG00000036997.1.
DR GeneTree; ENSGT00940000155619; -.
DR OMA; NFIRNTS; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR CDD; cd01472; vWA_collagen; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 8.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2265
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014371732"
FT DOMAIN 28..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 230..412
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 437..607
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 623..792
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 810..983
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1001..1172
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1188..1380
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1758..1903
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1966..2167
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1398..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2265 AA; 247335 MW; 3833B6D55FAB91E7 CRC64;
MKMLLILFLM IISSHISVNQ DSGPEYADVV FLVDSSDRLG SRSFPFVKMF ITKMISSLPI
EADKYRVALA QYSDKLHSEF HLSTFKGRSP MLNHLKKNFG FIGGSLQIGK ALQEAHRTFF
SAPTNGRDKK QFPPILVVLA SSESEDDVEE ASKALKKDGV KIISVGVQKA SEENLKAMAT
SQFHFNLRTV RDLSMFSQNM THIIKDVTKY KEGAVDDIFV EACQGPSMAD VVFLLDMSIN
GSDENFDYLK GFLEESVSAL DIKENCMRIG LVAYSNETKV INSLSMGINK SEVLQHIQNL
SHQTGKAYTG AAIKKLRKEV FSARNGSRKN QGVPQIAVLV THRDSEDNVT KAAVNLRREG
VTIFTLGIEG ASDTQLEKIA SHPAEQYVSK LKTFADLAAH NQTFLKKLRN QITHTVSVFS
ERTETLKSGC VDTEEADIYL LIDGSGSTQA TDFHEMKTFL SEVVGMFNIA PHKVRVGAVQ
YADSWDLEFE INKYSNKQDL GKAIENIRQI GGNTNTGAAL NFTLSLLQKA KKQRGNKVPC
HLVVLTNGMS KDSILEPANR LREEHIRVYA IGVKEANETQ LREIAGEEKR VYYVHDFDAL
KDIRNQVVQE ICAEEACKEM KADIMFLVDS SGSIGPENFS KMKTFMKNLV SKSQIGPDRV
QIGVVQFSDI NKEEFQLNRF MSQSDISNAI DQMAHIGQTT LTGSALSFVS QYFSPTKGAR
PNVRKFLILI TDGEAQDIVK EPAVALRQEG VIIYSVGVFG SNVTQLEEIS GRPEMVFYVE
NFDILQRIED DLVFGICSPR EECKRIEVLD VVFVIDSSGS IDYDEYNIMK NFMIDIVKKA
DVGKNRVQFG ALKYADDPEV LFYLDNFGTK PEVISVLQND QAMGGSTYTA EALGFSDHMF
TEARGSRLNK GVPQVLIVIT DGDSHDADKL NATAKALRDK GILVLAVGIA DANPVELLAM
AGSSDKYFFV ETFGGLKGIT SDVTASVCNS SKVDCEIDKV DLVFLMDGST SIQQTDFKKM
KEFLVSVVQD FDVSPNRVHI GAAQFSDAYR PEFPLGTFIG AKEISFQIEN ITQIFGNTHI
GAALRKVEHY FRPDMGSRIN TGTPQVLLIL TDGQSQDEVA QAAEALRHRG IDIYSVGIGD
VDDQQLIQIT GTAEKKLTVH NFDELKKVNK RIVRNICTTG SESNCFMDVV VGFDVSTQEK
GQTLLEGQPW METYLQDILR AISSLNGVSC EVGTETQVSV AFQVTNAMEK YSPKFEIYSE
NILNSLKDIT VKGPSFLNAN LLDSLWDTFQ NKSAARGKVV LLFSDGLDDD TEKLEQKSDE
LRKEGLNALM TVALDGPADS SDLADLPYIE FGKGFEYRTQ LSIGMRDLGS RLSKQLVNVA
ERTCCCLFCK CIGGDGSMGD PGPPGKRGPP GFKGSEGYLG EEGIAGERGA PGPVGEQGTK
GCYGTKGPKG NRGLNGQEGE TGESGIDGLN GEQGDYGLPG RKGEKGDEGS QGSPGKRGIP
GDHGAKGLRG DPGAPGVDNN IEGPTGLKGE RGREGRRGWP GPPGTPGSRR RTAAHGRRGH
TGPQGTAGIP GPDGLEGSLG LKGPQGPRGE AGAKGEKGGV GSKGPQGPPG PGGEAGNQGH
FGSQGNKGEP GDLGEKGAIG FPGPRGLQGD DGSPGYGSVG RKGAKGQGGF PGESGPKGET
GDPGGPGETG LKGARGKTIS AGLPGEMGSP GEPGPPGRKG VKGAKGLASF STCELIQYVR
DRSPGRRGKT ECPVHPTELV FALDQSRDVT EREFERMKEM MAFLVKDIKV RENSCPVGAR
IAILSYNSHA RHLVRFSDAY KKNQLLREIE AIPYERSSSS REIGRAMRFI SRNVFKRTLP
GAHTRRIATF FSSGQSADSQ SITTAAMEFS ALEIIPVVIT FSNVPSVRRA FAIDDTGTFQ
VIVVPSGADY IPALERLQQC TFCYDVCKPD ASCDQARPPP VQSYMDAAFL LDGSRNVGSA
EFEDIRAFLG ALLDHFEITP EPETSVTGDR VALLSHAPPD FLPNTQKSPV RAEFNLTTYS
SKRLMKRHVD ESVKQLNGDA FIGHALQWTL DNVFLTAPNL RRNKVIFVIS AGETSHLDGE
ILKKESLRAK CQGYALFVFS LGPTWDDKEL EDLASHPLDH HLVQLGRIHK PDHSYGVKFV
KTFINSIRRA INKYPPINLK IKCNRLNSAD PRQPLRHFRS FVPGPYKATL KEDVLQKAKF
FQDKKYLSRV ARSGRDDAIQ NFIRNTSHTF MNGRRVTKSA PKRVK
//