ID A0A2K6QDI1_RHIRO Unreviewed; 515 AA.
AC A0A2K6QDI1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Lysosomal cobalamin transport escort protein LMBD1 {ECO:0000256|ARBA:ARBA00039618};
DE AltName: Full=LMBR1 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042599};
GN Name=LMBRD1 {ECO:0000313|Ensembl:ENSRROP00000026838.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000026838.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000026838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR AlphaFoldDB; A0A2K6QDI1; -.
DR STRING; 61622.ENSRROP00000026838; -.
DR Ensembl; ENSRROT00000051107.1; ENSRROP00000026838.1; ENSRROG00000037176.1.
DR GeneTree; ENSGT00390000002581; -.
DR OMA; FWAQFVF; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035612; F:AP-2 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0140318; F:protein transporter activity; IEA:Ensembl.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR GO; GO:0038016; P:insulin receptor internalization; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Developmental protein {ECO:0000256|ARBA:ARBA00023218};
KW Gastrulation {ECO:0000256|ARBA:ARBA00023218};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 515 AA; 58953 MW; E41D6E97AA21058B CRC64;
MATPGAASAE LVIGWCIFGL LLLAILAFCW IYVRKYQSRR ESEVVSTITA IFSLAIALIT
SALLPVDIFL VSYMKNQNGT FKDWANANVS RQIEDTVLYG YYTLYSVILF CVFFWIPFVY
FYYEEKDDDD TSKCTQIKTA LKYTLGFVVI CALLLLVGAF VPLNVPNNKN STEWEKVKFL
FEELGSSAYG MSALPLNLIK GTRSAAYERL ENTEDIEEVE QHIQTIKSKS KDGRPLPARD
KRALKQFEER LRTLKKRERH LEFIENSWWT KFCGALRPLK IIWGVFFILV ALLFVISLFL
SNLDKALHSA GIDSGFIIFG ANLSNPLNML LPLLQTVFPL DYILITIIIM YFIFTSMAGI
RNIGIWFFWI RLYKIRRGRT RPQALLFLCM ILLLIVLHTS YMIYSLAPQY VMYGSQNYLI
ETNITSDNHK GNSTLSVPKR CDADAPEDQC TVTRTYLFLH KFWFFSAAYY FGNWAFLGVF
LIGLIVSCCK GKKSVIEGVD EDSDISDDEP SVYSV
//