ID A0A2K6QHZ4_RHIRO Unreviewed; 1753 AA.
AC A0A2K6QHZ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000256|ARBA:ARBA00014650};
DE AltName: Full=Hensin {ECO:0000256|ARBA:ARBA00030560};
GN Name=DMBT1 {ECO:0000313|Ensembl:ENSRROP00000028395.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000028395.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000028395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DMBT1 family.
CC {ECO:0000256|ARBA:ARBA00009931}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR Ensembl; ENSRROT00000052746.1; ENSRROP00000028395.1; ENSRROG00000037950.1.
DR GeneTree; ENSGT00950000183145; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 3.10.250.10; SRCR-like domain; 9.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF15; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00530; SRCR; 9.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00202; SR; 9.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF56487; SRCR-like; 9.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00420; SRCR_1; 7.
DR PROSITE; PS50287; SRCR_2; 9.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1753
FT /note="Deleted in malignant brain tumors 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014455324"
FT DOMAIN 103..203
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 234..334
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 355..455
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 463..563
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 593..693
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 722..822
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 853..953
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 984..1084
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1110..1221
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1227..1330
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1352..1461
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1470..1721
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT DISULFID 128..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 141..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 172..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 259..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 272..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 303..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 380..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 393..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 424..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 488..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 501..562
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 532..542
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 618..682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 631..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 662..672
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 747..811
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 760..821
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 791..801
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 878..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 891..952
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 922..932
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1009..1073
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1022..1083
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1053..1063
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1255..1319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1268..1329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1299..1309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1753 AA; 190093 MW; 24F1FF2F2F6EB9A0 CRC64;
MGISTVILEM CLLWGQVLPT GEWIPSTTDY GSLIPLEASL EVTSEEVSPF PSEAPLGSTR
VLEGSVFPSE TPLGSTVAEG SVFPSETPLG STVAEGSDYG LALRLVNGGD RCQGRVEVLY
QGSWGTVCDD SWDTNDANVV CRQLGCGWAT SAPGNARFGQ GSGSIVLDDV RCSGYESYLW
SCPHNGWLSH NCGHSEDAGV ICTAAQPQST LRPDSWPVRI SPVPTEGSES SLALRLVNGG
NRCQGRVEVL YRGSWGTVCD DSWDTSDANV VCRQLGCGWA TSAPGNARFG QGSGPIVLDD
VRCSGHESYL WSCPHSGWLS HNCQHSEDAG VICSDALPTT TLPASTVGPE SSLALRLVNG
GDRCQGRVEV LYRGSWGTVC DDSWDTNDAN VVCRQLGCGW ATSAPGNARF GQGSGPIVLD
DVRCSGNESY LWNCPHRGWL SHNCGHGEDA GVICSGPESS LALRLVNGAN RCQGRVEVLY
RGSWGTVCDD YWDTNDANVV CRQLDCGWAT SAPGNARFGQ GSGPIVLDDV RCSGHESYLW
SCPHSGWLSH NCGHGEDAGV ICSAAQSRLA RPDTLSTSTL PASTVGSESS LAVRLVNGSD
RCQGRVEVLY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT SAPGNARFGQ GSGPIVLDDV
RCSGQESYLW SCPHRGWLSH NCGHHEDAGV ICSVSQSQST PGPDTWPISR ASTAGSESSL
ALRLVNGGDR YQGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWATS APGNARFGQG
SGPIVLDDVG CSGHESYLWN CPHRGWLSHN CGHSEDAGVI CSAAQSQSTP RPDTWLTTNL
LTSPIGSESS LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTNDANVV CRQLGCGWAT
SAPGNARFGQ GSGPIVLDDV GCSGHESYLW NCPHRGWLSH NCGHSEDAGV ICSAAQSQST
PRPDALLTTN LLTSPIGSES SLALRLVNGG DRCQGRVEVL YRGSWGTVCD DSWDTNDANV
VCRQLGCGWA TSAPGNARFG QGSGPIVLDD VGCSGHESYL WNCPHRGWLS HNCGHSEDAG
VICSATQINS TTTDWWHPTT TTTTRPSSNC GGFLFSASGT FSSPSYPAYY PNNAKCVWEI
EVNSGYRINL GFSNLQLEVQ YNCSFDYVEI FDGSLNSSHL LGKICNDTRQ IFTSSYNRMT
IHFRSDISFQ NTGFLAWYNS FPSDATLRLV NLNSSYRLCA GRVEIYHGGT WGTVCDDSWT
IHEAEVVCRQ LGCGRAVSAL GNAYFGAGSG PITLDDVECS GTESTLWQCR NRGWFSHNCR
HNEDAGVICS GNPLSTPAPF LSITSPNTNY SCGGFLSQPS GDFSSPFYPR NYPNNAKCVW
DIKVQNNHRV TVIFRDVQLE GGCNYDYVEV FDGPYHSSPL IARVCDGARG SFTSSSNFMS
IRFVSDHSIT RRGFRAEYYS SPSNDSTNLL CLPNHMQASV SRSYLQSLGF SAHDLVISTW
NGYYECRSQI TPSLVIFTIP YSGCGTIKQA DNDTIDYSNF LTAAHVAPSR GIITRRKNFR
IHVSCRMLQN TWVDTMYIAN DTIQVEEVQY GNFDVNVSFY TSSSFLYPVT SHPYYVKLNQ
DLYVQAEILH SDAALTLFVD TCVASPYSND FTSLNYDLIR SGCVRDDTYG PYSQPSPHIA
RFRFRAFHFL NRFPSVYLHC KMVVCRAYDP SSRCNRGCVM RSKRDVGSYQ EKVDVVLGPI
QLQTPPRLEE EPQ
//
