ID A0A2K6QKK7_RHIRO Unreviewed; 3170 AA.
AC A0A2K6QKK7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=FRAS1 related extracellular matrix 2 {ECO:0000313|Ensembl:ENSRROP00000029312.1};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSRROP00000029312.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000029312.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000029312.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010359109.1; XM_010360807.1.
DR STRING; 61622.ENSRROP00000029312; -.
DR Ensembl; ENSRROT00000053711.1; ENSRROP00000029312.1; ENSRROG00000038462.1.
DR GeneID; 104660445; -.
DR KEGG; rro:104660445; -.
DR CTD; 341640; -.
DR GeneTree; ENSGT00940000155313; -.
DR OMA; ILPWELN; -.
DR OrthoDB; 5470912at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..47
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 48..3170
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014417184"
FT TRANSMEM 3109..3135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 320..414
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 439..538
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 561..676
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 701..808
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 829..920
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 946..1038
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1067..1169
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1190..1283
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1304..1400
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1421..1513
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1533..1622
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1656..1753
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1760..1859
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1872..1983
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2000..2104
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2119..2221
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2239..2343
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3037..3061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3142..3170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3154..3170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3170 AA; 351007 MW; C941BA0F2487AFA5 CRC64;
MHAAGTPGLS SRRTGNSTSL QPGPPPPTRL LLLLLLLLLS LVSRVPAQPA AFSRALLSPG
LAGAAGVPAE EAIVLANRGL RVPFGREVWL DPLHDLVLQV QPGDRCAVSV LDNDALAQRP
GRLSPKRFPC DFGPGEVHYS HLGARSPSRD RVRLQLRYDA PGGTVVLPLV LEVEVVFTQL
EVVTRNLPLV VEELLGTSNA LDARSLEFAY QLETEECRVG ILSGLGALPR YGELLHYPQV
PGGAGEGGAP EPLLMDCKAF QELGVRYRHT AASRSPNRDW MPMVVELRSR GAPVGSPALK
REHFQVLVRI RGGAENTAPK PSFVAMMMME VDQFVLTALT PDMLAAEDAE SPPDLLIFNL
TSPFQPGQGY LVSTDDRSLP LSSFTQRDLR LLKIAYQPPS EDSDQERLFE LELEVVDLEG
AASDPFAFMV VVKPMNTMAP VVTRNTGLIL YEGQSRPLTG PAGSGPQNLV ISDEDDLEAV
RLEVVAGLRH GHLVLLGASS GSSAPKSFTV AELAAGQVVY QHDDKDGSLS DNLVLRMVDG
GGRHQVQFLF PITLVPVDDQ PPVLNANTGL TLAEGETVPI LPLSLSATDM DSDDSLLLFV
LESPFLTTGH LLLRQTHPPH ETQELLRGLW RKEGAFYERT VTEWQQQDIT EGRLFYRHSG
PHSTGPVTDQ FTFRVQDNHD PPNQSGLQRF VIRIHPVDRL PPELGSGCPL RMVVQESQLT
PLRKKWLRYT DLDTDDRELR YTVTQPPTDT DENHSPAPLG TLVLTDNPSV VVTHFTQAQI
NHHKIAYRPP GQELGVATRV AQFQFQVEDR AGNVAPGTFT LYLQPVDNQP PEILNTGFTI
QEKGHHILSE TELHVNDVDT DVAHISFTLT QAPKHGHMRV SGQILHVGGL FHLEDIKQGR
VSYAHNGDKS LTDSCSLEVS DRHHVVPITL RVNVRPVDDE VPVLSHPTGT LESYLDVLEN
GATEVTANVI KGTSEETDDL MLTFLLEDPP LYGEILVNGI PAEQFTQRDI LEGSVVYTHT
SGEIGLLPKA DSFNLSLSDM SQEWRIGGNT IQGITMWVTI LPVDSQAPEI SVGEQLMVME
GDKSVITSMH ISAEDIDSLN DDILCTIVIQ PTSGYVENIS PAPGSEKSRA GIAISAFNLK
DLRQGHINYV QSVHKGVEPV EDRFIFRCSD GINFSERQFF PIVIIPTNDE QPEMFMREFM
VMEGMSLVID TPILNAADAD VPLDDLTFII TQFPTHGHIM NQLINGTVLV ESFTLDQIIE
SSSIIYEHDD SETQEDSFVI KLTDGKHSVE KMVLIIVIPV DDETPRMTIN NGLEIEIGDT
KIINNKILMA TDLDSEDKSL VYIIRYGPGH GLLQRRKPTG AFDNITLGMN FTQDEVDRNL
IQYVHLGREG IRDLIKFDVT DGINPLIDRY FYVSIGSIDI VFPDVISKGV SLKEGGKVTL
TTDLLSTSDL NSPDENLVFT ITRAPMRGHL ECTDQPGVSI TSFTQLQLAG NKIYYIHTAD
DEVKMDSFEF QVTDGRNPVF RTFRISISDV DNKKPVVTIH NLVVSESENK LITPFELTVE
DRDTPDKLLK FTITQVPIHG HLLFNNTRPV MVFTKQDLNE NLISYKHDGT ESSEDSFSFT
VTDGTHTDFY VFPNTVFETR RPQVMKIQVL AVDNSVPQIA VNKGASTLRT LVTGHLGFMI
TSKILKVEDR DSLHISLRFI VTEAPQHGYL LNLDKGNHSI AQFTQADIDD MKICYVLREG
ANATSDMFYF AVEDGGGNKV TNQHFRLNWA WISFEKEYYL INEDSKFLDV VLKRRGYLGE
TSFISIGTRD GTAEKDRDFK GKAQKQVQFN PGQTRATWRV RILSDGEHEQ SETFQVVLSE
PVLAALEFPT VATVEIIDPG DESTVFIPQS KYSIEEDVGE LFIPIRRSGD VSQELMVVCY
TQQGTATGTV PTSVLSYSDY ISRPEDHTSV VHFDKDEREK LCRIVIIDDS LYEEEETFHV
LLSMPMGGRI GSEFPGAQVT IVPDKDDEPI FYFGDVEYSV DESAGYVEVR VWRTGTDLSK
SSSVTVRSRK TDPPSADAGT DYVGISRNLD FAPGVNMQPV RVVILDDLGE PVLEGIEKFE
LVLRMPMNAA LGEPSKAIVS INDPVSDLPK MQFKERIYTG SESDGQIVTM IHRSGDVQYR
SSVRCYTRQG SAQVMMDFEE RPNTDISIIT FLPGETEKPC ILKLMDDMLY EEVEELRLVL
GTPQSNSPFG ATVGEQNETL IRIRDDADKT VIKFGETKFS VTEPKEPGES VVVRIPVIRQ
GDTSKVSIVR VHTKDGSATS GEDYHPVSEE IEFKEGETQH VVEIEVIFDG VREMREAFTV
HLTPDENMIA ETQVTKAIVY IEEMSSMADV TFPSVPQIVS LLMYDDTSKA KESAGPVSGY
PVICITACNP KYSDYDKTGS ICASENINDT LTRYRWLTSA PAGPDGVTSP MREVDFDTFF
TSSKMVTLDS IYFQPGSRVQ CAARAVNTNG DEGLELMSPT VTISREEGLC HPRVPGVVGA
EPFSAKLRYT GPEDPDYTNL IKLTVTMPHI DGMLPVISTR ELSNFELTLS PDGTRVGNHK
CSNLLDYTEV KTHYGFLTDA TKNPEIIGET YPYQYSLSIR GSNTLRFYRN LNLEACLWEF
VSYYDMSELL ADCGGTIGTD GQVLNLVQSY VTLRVPLYVS YVFHSPVGVG GWQHFDLKSE
LRLTFVYDTA ILWNDGIGSP PEAELQGSLY PTSMRIGDEG RLAVHFKTEA QFHGLFVLSH
PASFTSSVIM SADHPGLTFS LHLIRSEPTY NQPVQQWSFV SDFAVRDYSG TYTVKLVPCT
APSHQEYRLP VTCNPREPVT FDLDIRFQQV SDPVAAEFSL NTQMYLLSKK SLWLSDGSMG
FGQESDVAFA EGDIIYGRVM VDPVQNLGDS FYCSIEKVFL CTGADGYVPK YSPTNAEYGC
LADSPSLLYR FKIVDKAQPE TQATSFGNVL FNAKLAVDDP EAILLVNQPG SDGFKVDSTP
LFQVALGREW YIHTIYTVRS KDNANRGIGK RSVEYHSLVS QGKPQATTNS RKKREVRSTP
SLAWEIGAEN NRGTNIQHIA LDRTKRQIPQ GRVPPDGILP QELDSPSSAV SLVTVVGGTM
VGLLTICLTV IAVLMCRGKE SFRGKEAPKG SSSSEPMVPP QSHHNDSSEV
//
