ID A0A2K6QM54_RHIRO Unreviewed; 465 AA.
AC A0A2K6QM54;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sushi repeat-containing protein SRPX2 {ECO:0000256|ARBA:ARBA00014594};
GN Name=SRPX2 {ECO:0000313|Ensembl:ENSRROP00000029865.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000029865.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000029865.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_010378480.1; XM_010380178.1.
DR AlphaFoldDB; A0A2K6QM54; -.
DR STRING; 61622.ENSRROP00000029865; -.
DR Ensembl; ENSRROT00000054270.1; ENSRROP00000029865.1; ENSRROG00000038719.1.
DR GeneID; 104675583; -.
DR KEGG; rro:104675583; -.
DR CTD; 27286; -.
DR GeneTree; ENSGT00940000159149; -.
DR OMA; EQRDMCE; -.
DR OrthoDB; 5406861at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0036458; F:hepatocyte growth factor binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0042325; P:regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0071625; P:vocalization behavior; IEA:Ensembl.
DR CDD; cd00033; CCP; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; HYR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46343:SF3; SUSHI REPEAT-CONTAINING PROTEIN SRPX2; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..465
FT /note="Sushi repeat-containing protein SRPX2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014371744"
FT DOMAIN 69..119
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 120..178
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 177..261
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 262..321
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 149..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 292..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 465 AA; 52998 MW; 5C3EB4E43C712A13 CRC64;
MASQLTQRGA LSLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPRAPA LDYRVPRWCY
TLNIQDGEAT CYSPRGGNYH SSLGTRCELS CDRGFRLIGR RSVQCLPSRR WSGTAYCRQM
RCHALPFITS GTYTCTNGVL LDSRCDYSCS SGYHLEGDRS RICMEDGRWS GGEPVCVDID
PPKIRCPHSR EKMAEPEKLT ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR
YTAYDRAYNR ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG
TPSRVCQSSR QWSGSPPICT PMKINVNVNS AAGLLDQFYE KQRLLIISAP DPSNRYYKMQ
ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN IIEELRQFQR LTRSYFNMVL
IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS NQELTQRREQ RDICE
//
