ID A0A2K6QMR3_RHIRO Unreviewed; 3561 AA.
AC A0A2K6QMR3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transformation/transcription domain associated protein {ECO:0000313|Ensembl:ENSRROP00000030073.1};
GN Name=TRRAP {ECO:0000313|Ensembl:ENSRROP00000030073.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000030073.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000030073.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR Ensembl; ENSRROT00000054477.1; ENSRROP00000030073.1; ENSRROG00000038566.1.
DR GeneTree; ENSGT00390000017961; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 2387..2959
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3202..3525
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3529..3561
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 186..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1718..1739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2238..2273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2969..2991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..220
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2971..2990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3561 AA; 402697 MW; 2DD19F52506E2F06 CRC64;
LLKTLTSLEL VTKYSQQMVK GMLQLLSNCP AETAHLRKEL LIAAKHILTT ELRNRTSDLS
SEVSARRPLA YSTLADLVHH VRQHLPLSDL SLAVQLFAKN IDDESLPSSI QTMSCKLLLN
LVDCIRSKSE QESGNGRDVL MRMLEVFVLK FHTIARYQLS AIFKKCKPQS ELGAVEAALP
GVPTAPAAPG PAPSPAPVPA PAPPPPPPPP ATPVTPAPVP PFEKQGEKDK EDKQTFQVTD
CRSLVKTLVC GVKTITWGIT SCKAPGEAQF IPNKQLQPKE TQIYIKLVKY AMQALDIYQV
QIAGNGQTYI RVANCQTVRM KEEKEVLEHF AGVFTMMNPL TFKEIFQTTV PYMVERISKN
YALQIVANSF LANPTTSALF ATILVEYLLD RLPEMGSNVE LSNLYLKLFK LVFGSVSLFA
AENEQMLKPH LHKIVNSSME LAQTAKEPYN YFLLLRALFR SIGGGSHDLL YQEFLPLLPN
LLQGLNMLQS GLHKQHMKDL FVELCLTVPV RLSSLLPYLP MLMDPLVSAL NGSQTLVSQG
LRTLELCVDN LQPDFLYDHI QPVRAELMQA LWRTLRNPAD SISHVAYRVL GKFGGSNRKM
LKESQKLHYV VTEVQGPSIT VEFSDCKASL QLPMEKAIET ALDCLKSANT EPYYRRQAWE
VIKCFLVAMM SLEDNKHALY QLLAHPNFTE KTIPNVIISH RYKAQDTPAR KTFEQALTGA
FMSAVIKDLR PSALPFVASL IRHYTMVAVA QQCGPFLLPC YQVGSQPSTA MFHSEENGSK
GMDPLVLIDA IAICMAYEEK ELCKIGEVAL AVIFDVASII LGSKERACQL PLFSYIVERL
CACCYEQAWY AKLGGVVSIK FLMERLPLTW VLQNQQTFLK ALLFVMMDLT GEVSNGAVAM
AKTTLEQLLM RCATPLKDEE RAEEIVAAQE KSFHHVTHDL VREVTSPNST VRKQAMHSLQ
VLAQVTGKSV TVIMEPHKEV LQDMVPPKKH LLRHQPANAQ IGLMEGNTFC TTLQPRLFTM
DLNVVEHKVF YTELLNLCEA EDSALTKLPC YKSLPSLVPL RIAALNALAA CNYLPQSREK
IIAALFKALN STNSELQEAG EACMRKFLEG ATIEVDQIHT HMRPLLMMLG DYRSLTLNVV
NRLTSVTRLF PNSFNDKFCD QMMQHLRKWM EVVVITHKGG QRSDGNESIS ECGRCPLSPF
CQFEEMKICS AIINLFHLIP AAPQTLVKPL LEVVMKTERA MLIEAGSPFR EPLIKFLTRH
PSQTVELFMM EATLNDPQWS RMFMSFLKHK DARPLRDVLA ANPNRFITLL LPGGAQTAVR
PGSPSTSTMR LDLQFQAIKI ISIIVKNDDS WLASQHSLVS QLRRVWVSET FQERHRKENM
AATNWKEPKL LAYCLLNYCK RNYGDIELLF QLLRAFTGRF LCNMTFLKEY MEEEIPKNYS
ITQKRALFFR FVDFNDPNFG DELKAKVLQH ILNPAFLYSF EKGEGEQLLG PPNPEGDNPE
SITSVFITKV LDPEKQADML DSLRIYLLQY ATLLVEHAPH HIHDNNKNRN SKLRRLMTFA
WPCLLSKACV DPACKYSGHL LLAHIIAKFA IHKKIVLQVF HSLLKAHAME ARAIVRQAMA
ILTPAVPARM EDGHQMLTHW TRKIIVEEGH TVPQLVHILH LIVQHFKVYY PVRHHLVQHM
VSAMQRLGFT PSVTIEQRRL AVDLSEVVIK WELQRIKDQQ PDSDMDPNSS GEGVNSVSSS
IKRGLSVDSA QEVKRFRTAT GAISAVFGRS QSLPGADSLL AKPIDKQHTD TVVNFLIRVA
CQVNDNTNTA GSPGEVLSRR CVNLLKTALR PDMWPKSELK LQWFDKLLMT VEQPNQVNYG
NICTGLEVLS FLLTVLQSPA ILSSFKPLQR GIAACMTCGN TKVLRAVHSL LSRLMSIFPT
EPSTSSVASK YEELECLYAA VGKVIYEGLT NYEKATNANP SQLFGTLMIL KSACSNNPSY
IDRLISVFMR SLQKMVREHL NPQAASGSTE ATSGTSELVM LSLELVKTRL AVMSMEMRKN
FIQAILTSLI EKSPDAKILR AVVKIVEEWV KSNSPMAANQ TPTLREKSIL LVKMMTYIEK
RFPEDLELNA QFLDLVNYVY RDETLSGSEL TAKLEPAFLS GLRCAQPLIR AKFFEVFDNS
MKRRVYERLL YVTCSQNWEA MGNHFWIKQC IELLLAVCEK STPIGTSCQG AMLPSITNVI
NLADSHDRAA FAMVTHVKQE PRERENSESK EEDVEIDIEL APGDQTSTPK TKELSEKDIG
NQLHMLTNRH DKFLDTLREV KTGALLSAFV QLCHISTTLA EKTWVQLFPR LWKILSDRQQ
HALAGEISPF LCSGSHQVQR DCQPSALNCF VEAMSQCVPP IPIRPCVLKY LGKTHNLWFR
STLMLEHQAF EKGLSLQIKP KQTTEFYEQE SITPPQQEIL DSLAELYSLL QEEDMWAGLW
QKRCKYSETA TAIAYEQHGF FEQAQESYEK AMDKAKKEHE RSNASPAIFP EYQLWEDHWI
RCSKELNQWE ALTEYGQSKG HINPYLVLEC AWRVSNWTAM KEALVQVEVS CPKEMAWKVN
MYRGYLAICH PEEQQLSFIE RLVEMASSLA IREWRRLPHV VSHVHTPLLQ AAQQIIELQE
AAQINAGLQP TNLGRNNSLH DMKTVVKTWR NRLPIVSDDL SHWSSIFMWR QHHYQAIVTA
YENSSQHDPS SNNAMLGVHA SASAIIQYGK IARKQGLVNV ALDILSRIHT IPTVPIVDCF
QKIRQQVKCY LQLAGVMGKN ECMQGLEVIE STNLKYFTKE MTAEFYALKG MFLAQINKSE
EANKAFSAAV QMHDVLVKAW AMWGDYLENI FVKERQLHLG VSAITCYLHA CRHQNESKSR
KYLAKVLWLL SFDDDKNTLA DAVDKYCIGV PPIQWLAWIP QLLTCLVGSE GKLLLNLISQ
VGRVYPQAVY FPIRTLYLTL KIEQRERYKS DSGQQQPSSV GNQSHSASDP GPIRATAPMW
RCSRIMHMQR ELHPTLLSSL EGIVDQMVWF RENWHEEVLR QLQQGLAKCY SVAFEKSGAV
SDAKITPHTL NFVKKLVSTF GVGLENVSNV STMFSSAASE SLARRAQATA QDPVFQKLKG
QFTTDFDFSV PGSMKLHNLI SKLKKWIKIL EAKTKQLPKF FLIEEKCRFL SNFSAQTAEV
EIPGEFLMPK PTHYYIKIAR FMPRVEIVQK HNTAARRLYI RGHNGKIYPY LVMNDACLTE
SRREERVLQL LRLLNPCLEK RKETTKRHLF FTVPRVVAVS PQMRLVEDNP SSLSLVEIYK
QRCAKKGIEH DNPISRYYDR LATVQARGTQ ASHQVLRDIL KEVQSNMVPR SMLKEWALHT
FPNATDYWTF RKMFTIQLAL IGFAEFVLHL NRLNPEMLQI AQDTGKLNVA YFRFDINDAT
GDLDANRPVP FRLTPNISEF LTTIGVSGPL TASMIAVARC FAQPNFKVDG ILKTVLRDEI
IAWHKKTQED TSSPLSAAGQ PENMDSQQLV SLVQKAVTAI MTRLHNLAQF EGGESKVNTL
VAAANSLDNL CRMDPAWHPW L
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