ID A0A2K6QMX5_RHIRO Unreviewed; 98 AA.
AC A0A2K6QMX5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Vesicle-associated membrane protein 8 {ECO:0000256|ARBA:ARBA00039271};
DE AltName: Full=Endobrevin {ECO:0000256|ARBA:ARBA00042205};
GN Name=VAMP8 {ECO:0000313|Ensembl:ENSRROP00000030120.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000030120.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000030120.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004521};
CC Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004521}.
CC Early endosome membrane {ECO:0000256|ARBA:ARBA00037832}; Single-pass
CC type IV membrane protein {ECO:0000256|ARBA:ARBA00037832}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane
CC protein {ECO:0000256|ARBA:ARBA00037867}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00037845}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037845}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00037863}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037863}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}. Zymogen granule membrane
CC {ECO:0000256|ARBA:ARBA00037825}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037825}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR AlphaFoldDB; A0A2K6QMX5; -.
DR Ensembl; ENSRROT00000054524.1; ENSRROP00000030120.1; ENSRROG00000038818.1.
DR GeneTree; ENSGT00940000160325; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042589; C:zymogen granule membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR001388; Synaptobrevin-like.
DR InterPro; IPR016444; Synaptobrevin/VAMP.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45701; SYNAPTOBREVIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45701:SF7; VESICLE-ASSOCIATED MEMBRANE PROTEIN 8; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU00290}; Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 12..75
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
SQ SEQUENCE 98 AA; 11090 MW; 2DDBE1A5F04D924A CRC64;
MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATPGPEGS
CFREEVTPKL SKVWSLRFCV QLGSWLWLSS CVNSWLLV
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