ID A0A2K6QNA5_RHIRO Unreviewed; 1536 AA.
AC A0A2K6QNA5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSRROP00000030291.1};
GN Name=ARAP3 {ECO:0000313|Ensembl:ENSRROP00000030291.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000030291.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000030291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSRROT00000054697.1; ENSRROP00000030291.1; ENSRROG00000038877.1.
DR GeneTree; ENSGT00940000158869; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17902; ArfGap_ARAP3; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 8..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 318..369
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 384..473
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 470..601
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 899..1080
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1109..1202
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1215..1317
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 64..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1502..1536
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1536 AA; 169164 MW; F540BCCF8E83ECEA CRC64;
MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAAWGLG HEELKQLGIS ATGHRKRILR
LLQTGTEEGS LDPKSDSAME PSSSPAPKTQ PPKPVPKPRT VFGGLSGPAT TQRPGLSPVL
GEPGVSRSPE PSPRPPPLPT SSTEQSSALN TVEMMPNSIY FGLDLRGKAQ AAQENNLLFP
VHSPLLLPVH IMDPGCLYYG VQPVGTPGAP DRREGRGVCQ DRAEHRLSRQ DLEAREDAGY
ASLELPGDST LLSPTLETEE TSDDLISPYA SFSFTADRPT PLLSGWLDKL SPQGWVLGRE
GREKREAGRW LHGKDPFPKG VIPLTAIEMT RSSKDNKFQV ITGQRVFVFR TESEAQRDTW
CSTLQSCLKE QRLLGHPRPP QPPRPLRTGM LELRGHKAKV FAALSPGELA LYKSEQAFSL
GIGICFIELQ GCSVRETKSR SFDLLTPHRC FSFTAESGGA RQSWAAALQE AVTETLSDYE
VAEKIWSNRA NRHCADCGSS RPDWAAVNLG VVICKQCAGQ HRALGSGISK VQSLKLDTSV
WSNEIVQLFI VLGNDRANRF WAGTLPPGEG LHPDATPGPR GEFISRKYRL GLFRKPHPQY
PDHSQLLQAL CAAVAGPNLL KNMTQLLCVE AFEGEEPWSP PTLDGSCPGL MPPDPSPGVY
NEVVVPATYS GFLYCGPVTN KAGPSPPRRG RDAPPRLWCV LGAALEMFAS ENSPEPLSLI
QPQDIVCLGV SPPPTDPGDL DRFPFSFELI LTGGRIQHFG TDGADSLEAW TSAVGKWFSP
LSCHQLLGPG LLRLGRLWLR SPSHTAPAPG VWLSGFGLLR GDHLFLCSAP GPGPPAPEDM
VHLRRLQEIS VVSAADTPDK KEYLVLVETG RTLYLQGEGR LDFTAWNTAI GGAAGGGGTG
LQEQQMSRGD IPIIVDACIS FVTQHGLRLE GVYRKGGARA RSLKLLAEFR RDARSVKLRP
GEHFVEDVTD TLKRFFRELD DPVTSARLLP RWREAAELPQ KNQRLEKYKD VIGCLPRVNR
RTLATLIGHL YRVQKCAALN QMCTRNLALL FAPSVFQTDG RGEHEVRVLQ ELIDGYISVF
DIDSDQVAQI DLEVSLITTW KDVQLSQAGD LIMEVYVEQQ LPDNCVTLKV SPTLTAEELT
NQVLEMRGTA AGMDLWVTFE IREHGELERP LHPKEKVLEQ ALQWCQLPEP CSASLLLKKV
PLAQAGCLFT GIRRESPRVG LLRCREEPPR LLGSRFQERF FLLRGRCLLL LKEKKSSKPE
REWPLEGAKV FLGIRKKLKP PTPWGFTLIL EKMHLYLSCT DEDEMWDWTT SILKAQHDDQ
QPVVLRRRSS SDLARQKFGT MPLLPIRGDD SGATLLSANQ TLRQLHNRRT LSMFFPMKSS
QGSVEEQEEL EEPVYEEPVY EEVGAFPELT QDTSTSFSIT REWTVKPENP LTSQKSLDQP
FLSKSSTLGQ EERLPEPPPG PLSKSSPQAR GSLEEQLLQE LSSLILRKGE TTAGLGSPSQ
PSSPQSPSPT GLPTQTPGFP TQPPCTSSPP SSHPLT
//