ID A0A2K6QQN9_RHIRO Unreviewed; 350 AA.
AC A0A2K6QQN9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Thioredoxin related transmembrane protein 4 {ECO:0000313|Ensembl:ENSRROP00000031064.1};
GN Name=TMX4 {ECO:0000313|Ensembl:ENSRROP00000031064.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000031064.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000031064.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010386079.1; XM_010387777.1.
DR RefSeq; XP_010386080.1; XM_010387778.1.
DR AlphaFoldDB; A0A2K6QQN9; -.
DR STRING; 61622.ENSRROP00000031064; -.
DR Ensembl; ENSRROT00000055476.1; ENSRROP00000031064.1; ENSRROG00000039242.1.
DR GeneID; 104681480; -.
DR KEGG; rro:104681480; -.
DR CTD; 56255; -.
DR GeneTree; ENSGT00940000160301; -.
DR OMA; CGSNWSL; -.
DR OrthoDB; 2909094at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02994; PDI_a_TMX; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46107; DUMPY: SHORTER THAN WILD-TYPE; 1.
DR PANTHER; PTHR46107:SF1; THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 4; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014475523"
FT TRANSMEM 189..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..140
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 224..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..289
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 39106 MW; 00A541FD834E4616 CRC64;
MAGGRYGPQL LALLAAWVAA VAATAGPEQA ALPAEQSRVQ PMTASNWTLV MEGEWMLKFY
APWCPSCQQT DSEWETFAKN GEMLQISVGK VDVIQEPGLS GRFFVTTLPA FFHAKDGIFR
RYRGPGIFED LQNYILEKKW QSVEPLTGWK SPASLTMSGM AGLFSISGKI WHLHNYFTVT
LGIPAWCSYV FFVIATLVFG LFMGLVLVVI SECFYVPLPR HLSERSEENG RSEEAHRAEQ
LQDAEEEKDD SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEEDNLAAGV DEERSEANDQ
GPPGEDSVTR EELEPEEAEE GISEKPCPAD TEVVEDSLRQ RKSQHADKGL
//
