ID   A0A2K6QS62_RHIRO        Unreviewed;       913 AA.
AC   A0A2K6QS62;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSRROP00000031628.1};
GN   Name=RALGDS {ECO:0000313|Ensembl:ENSRROP00000031628.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000031628.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000031628.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010371112.1; XM_010372810.1.
DR   AlphaFoldDB; A0A2K6QS62; -.
DR   Ensembl; ENSRROT00000056044.1; ENSRROP00000031628.1; ENSRROG00000039481.1.
DR   GeneID; 104669737; -.
DR   CTD; 5900; -.
DR   GeneTree; ENSGT00940000153181; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17209; RA_RalGDS; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR015758; RalGDS_RA.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          111..248
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          385..647
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          797..884
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          280..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..354
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        736..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   913 AA;  100457 MW;  A840D61B725C7EC2 CRC64;
     MAREAGQVCA RPAVPRVGKG SVFFACVSVV TARRRAIARR AALQSPTPWL APLPPPTTTE
     SSTQEIGEEL INGVIYSISL RKVQLHHGAN KGQRWLGYEN ESALNLYETC KVRTVKAGTL
     EKLVEHLVPA FQGSDLSYVT IFLCTYRAFT TTQQVLDLLF KRYGRCDALT ASSRYGCVLP
     YSDEDGGPQD QLKNAISSIL GTWLDQYSED FCQPPDFPCL KQLVAYVQLN MPGSDLERRA
     HLLLAQLEHS EPIEAEPEAL SPVPAVKPTP ELELALTPAR APSPLPVPAP APTPASGSEL
     EVAPPPAPKL QQAPEPAVEL EPAPAPAPEL EPAPVPPPEQ DPAPSQTLEL EPAPVPVPSL
     EPSWPSPVVA ENGLSEEKPH LLVFPPDLVA EQFTLMDAEL FKKVVPYHCL GSIWSQRDKK
     GKEHLAPTIR ATVTQFNSVA NCVITTCLGD RSTKAPDRAR VVEHWIEVAR ECRILKNFSS
     LYAILSALQS NSIHRLKKTW EDVSRDSFRI FQKLSEIFSD ENNYSLSREL LIKEGTSKFA
     TLEMNPKRAQ KRPKETGIIQ GTVPYLGTFL TDLVMLDTAM KDYLYGRLIN FEKRRKEFEV
     IAQIKLLQSA CNNYSITPDE QFGVWFRAVE RLSETESYNL SCELEPPSES ASNTLRTKKN
     TAIVKRWSDR QAPSTELSTS GSSHSKSCDQ LRCGPYLSSG DIADALSVHS AGSSSSDVEE
     INISFVPESP DGQEKKFWES ASQSSPETSG ISSASSSTSS SSASTTPVAA TRTHKRSVSG
     LCNSSSALPL YNQQVGDCCI IRVSLDVDNG NMYKSILVTS QDKAPAVIRK AMDKHNLEED
     EPEDYELLQI LSDDRKLKIP ENANVFYAMN STANYDFVLK KRTFTKGVKV KHGASSTLPR
     MKQKGLKIAK GIF
//