ID A0A2K6QSG0_RHIRO Unreviewed; 1699 AA.
AC A0A2K6QSG0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Kinesin family member 1A {ECO:0000313|Ensembl:ENSRROP00000031696.1};
GN Name=KIF1A {ECO:0000313|Ensembl:ENSRROP00000031696.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000031696.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000031696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSRROT00000056112.1; ENSRROP00000031696.1; ENSRROG00000039338.1.
DR GeneTree; ENSGT00940000156474; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22726; FHA_KIF1A; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR049779; FHA_KIF1A.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..352
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 514..570
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1584..1682
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1421..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 428..455
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 626..660
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1427..1445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1699 AA; 192104 MW; F5C5486AF802936C CRC64;
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMVS GPNKKKKKTD
FIPYRDSVLT WLLRENLGGN SRTAMVAALS PADINYDETL STLRYADRAK QIRCNAVINE
DPNNKLIREL KDEVTRLRDL LYAQGLGDIT DMTNALVGMS PSSSLSALSS RAASVSSLHE
RILFAPGSEE AIERLKETEK IIAELNETWE EKLRRTEAIR MEREALLAEM GVAMREDGGT
LGVFSPKKTP HLVNLNEDPL MSECLLYYIK DGITRVGRED GERRQDIVLS GHFIKEEHCV
FRSDSRGGSE AVVTLEPCEG ADTYVNGKKV TEPSILRSGN RIIMGKSHVF RFNHPEQARQ
ERERTPCAET PAEPVDWAFA QRELLEKQGI DMKQEMEQRL QELEDQYRRE REEATYLLEQ
QRLDYESKLE ALQKQMDSRY YPEVNEEEEE PEDEVQWTER ECELALWAFR KWKWYQFTSL
RDLLWGNAIF LKEANAISVE LKKKVQFQFV LLTDTLYSPL PPDLLPPEAA KDRETRPFPR
TIVAVEVQDQ KNGATHYWTL EKLRQRLDLM REMYDRAAEV PSSVIEDCDN VVTGGDPFYD
RFPWFRLVGR AFVYLSNLLY PVPLVHRVAI VSEKGEVKGF LRVAVQAISA DEEAPDYGSG
VRQSGTAKIS FDDQHFEKFQ SESCPVVGMS RSGTSQEELR IVEGQGQGAD VGPSADEVNN
NTCSAVPPEG LHLDSSEKAA LDGPLDTALD HLRLGSTFTF RVTVLQASSI SAEYADIFCQ
FNFIHRHDEA FSTEPLKNTG RGPPLGFYHV QNIAVEVTKS FIEYIKSQPI VFEVFGHYQQ
HPFPPLCKDV LSPLRPSRRH FPRVMPLSKP VPATKLSTLT RPCPGPCHCK YDLLVYFEIC
ELEANGDYIP AVVDHRGGMP CMGTFLLHQG IQRRITVTLL HETGSHIRWK EVRELVVGRI
RNTPETDESL IDPNILSLNI LSSGYIHPAQ DDRQFLDSDI PRTFYQFEAA WDSSMHNSLL
LNRVTPYREK IYMTLSAYIE MENCTQPAVI TKDFCMVFYS RDAKLPASRS IRNLFGSGSL
RASERDSHPG LGAGQVWLCL AAVLGPPGMQ RRRRRVLDTS VAYVRGEENL AGWRPRSDSL
ILDHQWELEK LSLLQEVEKT RHYLLLREKL ETTQRPIPEA LSPAFSEDSE SHGSSSASSP
LSTEGRPSPL EAPNERQREL AVKCLRLLTH TFNREYTHSH VCVSASESKL SEMSVTLLRD
PSMSPLGAAT LTPSSTCPSL VEGRYGATDL RTPQPCSRPA SPEPELLPEA DSKKLPSPAR
ATETDKEPQR LLVPDIQEIR VSPIVSKKGY LHFLEPHTSG WARRFVVVRR PYAYMYNSDK
DTVERFVLNL ATAQVEYSED QQAMLKTPNT FAVCTEHRGI LLQAASDKDM HDWLYAFNPL
LAGTIRSKLS RRRSAQMRV
//
