ID A0A2K6QTU6_RHIRO Unreviewed; 4484 AA.
AC A0A2K6QTU6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=LDL receptor related protein 1 {ECO:0000313|Ensembl:ENSRROP00000032191.1};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSRROP00000032191.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000032191.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000032191.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 61622.ENSRROP00000032191; -.
DR Ensembl; ENSRROT00000056617.1; ENSRROP00000032191.1; ENSRROG00000039596.1.
DR GeneTree; ENSGT00940000157899; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0016964; F:alpha-2 macroglobulin receptor activity; IEA:Ensembl.
DR GO; GO:0034185; F:apolipoprotein binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IEA:Ensembl.
DR GO; GO:0150093; P:amyloid-beta clearance by transcytosis; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 28.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 27.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 26.
DR Pfam; PF00058; Ldl_recept_b; 11.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 28.
DR SMART; SM00135; LY; 34.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 27.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 14.
DR PROSITE; PS50068; LDLRA_2; 28.
DR PROSITE; PS51120; LDLRB; 25.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4364..4384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 347..390
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 391..434
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 583..625
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 626..671
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 672..722
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 723..766
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1321..1367
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1368..1410
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1411..1457
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1458..1502
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1639..1681
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1682..1725
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1726..1765
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1946..1988
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1989..2031
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2032..2075
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2076..2119
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2356..2400
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2401..2443
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2982..3017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3069..3113
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3114..3156
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3157..3200
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3201..3243
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3910..3952
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3953..3996
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4136..4169
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4172..4208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4209..4241
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4244..4280
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4315..4349
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 866..878
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 873..891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 907..919
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 914..932
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 948..960
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 955..973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 996..1014
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1008..1023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1027..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1034..1052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1094..1109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1137..1152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2544..2562
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2611..2629
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2623..2638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2673..2688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2696..2708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2703..2721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2715..2730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2734..2746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2741..2759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2818..2830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2825..2843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2858..2870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2912..2930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2924..2939
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2986..2996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3334..3346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3341..3359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3374..3386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3381..3399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3393..3408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3433..3448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3494..3506
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3501..3519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3553..3565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3560..3578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3572..3587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3594..3606
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3601..3619
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3656..3671
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3689..3707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3701..3716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4140..4150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4176..4186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4198..4207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4212..4222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4248..4258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4270..4279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4317..4327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4339..4348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4484 AA; 498411 MW; 558E0567DE4763CD CRC64;
METDAREGRG VLRNFRATES ASTLHLYTLS FLALAPKTCS PKQFACRDQI TCISKGWRCD
GERDCPDGSD EAPEICPQSK AQRCQPNEHN CLGTELCVPM SRLCNGVQDC MDGSDEGPHC
RELRGNCSRL GCQHHCVPTL DGPTCYCNSS FQLQADSKTC KDFDECSVYG TCSQLCTNTD
GSFICGCVEG YLLQPDNRSC KAKNEPVDRP PVLLIANSQN ILATYLSGAQ VSTITPTSTR
QTTAMDFSYA NETVCWVHVG DNAAQTQLKC ARMPGLKGFV DEHTINISLS LHHVEQMAID
WLTGNFYFVD DIDDRIFVCN RNGDTCVTLL DLELYNPKGI ALDPAMGKVF FTDYGQIPKV
ERCDMDGQNR TKLVDSKIVF PHGITLDLVS RLVYWADAYL DYIEVVDYEG KGRQTIIQGI
LIEHLYGLTV FENYLYATNS DNANAQQKTS VIRVNRFNST EYQVVTRVDK GGALHIYHQR
RQPRVRSHAC ENDQYGKPGG CSDICLLANS HKARTCRCRS GFSLGSDGKS CKKPEHELFL
VYGKGRPGII RGMDMGAKVP DEHMIPIENL MNPRALDFHA ETGFIYFADT TSYLIGRQKI
DGTERETILK DGIHNVEGVA VDWMGDNLYW TDDGPKKTIS VARLEKAAQT RKTLIEGKMT
HPRAIVVDPL NGWMYWTDWE EDPKDSRRGR LERAWMDGSH RDIFVTSKTV LWPNGLSLDI
PAGRLYWVDA FYDRIETILL NGTDRKIVYE GPELNHAFGL CHHGNYLFWT EYRSGSVYRL
ERGVGGAPPT VTLLRSERPP IFEIRMYDAQ QQQVGTNKCR VNNGGCSSLC LATPGSRQCA
CAEDQVLDAD GVTCLANPSY VPPPQCQPGE FACANSRCIQ ERWKCDGDND CLDNSDEAPA
LCHQHTCPSD RFKCENNRCI PNRWLCDGDN DCGNSEDESN ATCSARTCPP NQFSCASGRC
IPISWTCDLD DDCGDRSDES ASCAYPTCFP LTQFTCNNGR CININWRCDN DNDCGDNSDE
AGCSHSCSST QFKCNSGRCI PEHWTCDGDN DCGDYSDETH ANCTNQATRP PGGCHTDEFQ
CRLDGLCIPL RWRCDGDTDC MDSSDEKSCE GVTHVCDPSV KFGCKDSARC ISKAWVCDGD
NDCEDNSDEE NCESLACRPP SHPCANNTSV CLPPDKLCDG NDDCGDGSDE GELCDQCSLN
NGGCSHNCSV APGEGIVCSC PLGMELGPDN HTCQIQSYCA KHLKCSQKCD QNKFSVKCSC
YEGWVLEPDG ESCRSLDPFK PFIIFSNRHE IRRIDLHKGD YSVLVPGLRN TIALDFHLSQ
SALYWTDVVE DKIYRGKLLD NGALTSFEVV IQYGLATPEG LAVDWIAGNI YWVESNLDQI
EVAKLDGTLR TTLLAGDIEH PRAIALDPRD GILFWTDWDA SLPRIEAASM SGAGRRTVHR
ETGSGGWPNG LTVDYLEKRI LWIDARSDAI YSARYDGSGH MEVLRGHEFL SHPFAVTLYG
GEVYWTDWRT NTLAKANKWT GHNVTVVQRT NTQPFDLQVY HPSRQPMAPN PCEANGGRGP
CSHLCLINYN RTVSCACPHL MKLHKDKTTC YEFKKFLLYA RQMEIRGVDL DAPYYNYIIS
FTVPDIDNVT VLDYDAREQR VYWSDVRTQA IKRAFINGTG VETVVSADLP NAHGLAVDWV
SRNLFWTSYD TNKKQINVAR LDGSFKNAVV QGLEQPHGLV VHPLRGKLYW TDGDNISMAN
MDGSNRTLLF SGQKGPVGLA IDFPESKLYW ISSGNHTINR CNLDGSGLEV IDAMRSQLGK
ATALAIMGDK LWWADQVSEK MGTCSKADGL GSVVLRNSTT LVMHMKVYDE SIQLDHKGTN
PCSVNNGDCS QLCLPTSETT RSCMCTAGYS LRSGQQACEG VGSFLLYSVH EGIRGIPLDP
NDKSDALVPV SGTSLAVGID FHAENDTIYW VDMGLSTISR AKRDQTWRED VVTNGIGRVE
GIAVDWIAGN IYWTDQGFDV IEVARLNGSF RYVVISQGLD KPRAITVHPE KGYLFWTEWG
QYPRIERSRL DGTERVVLVN VSISWPNGIS VDYQDGKLYW CDARTDKIER IDLETGENRE
VVLSSNNMDM FSVSVFEDFI YWSDRTHANG SIKRGSKDNA TDSVPLRTGI GVQLKDIKVF
NRDRQKGTNV CAVANGGCQQ LCLYRGRGQR ACACAHGMLA EDGASCREYA GYLLYSERTI
LKSIHLSDER NLNAPVQPFE DPEHMKNVIA LAFDYRAGTS PGTPNRIFFS DIHFGNIQQI
NDDGSRRITI VENVGSVEGL AYHRGWDTLY WTSYTTSTIT RHTVDQTRPG AFERETVITM
SGDDHPRAFV LDECQNLMFW TNWNEQHPSI MRAALSGANV LTLIEKDIRT PNGLAIDHRA
EKLYFSDATL DKIERCEYDG SHRYVILKSE PVHPFGLAVY GEHIFWTDWV RRAVQRANKH
VGSNMKLLRV DIPQQPMGII AVANDTNSCE LSPCRINNGG CQDLCLLTHQ GHVNCSCRGG
RILQDDLTCR AVNSSCRAQD EFECANGECI NFSLTCDGVP HCKDKSDEKP SYCTQVLLPQ
LMKGRTTVSL YWAFGLGGGS PFPVPKTFRQ CSNGRCVSNM LWCNGADDCG DGSDEIPCNS
ATDCSSYFRL GVKGVLFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY
FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG
DGSDEAAHCE GKTCGPSSFS CPGTHVCVPE RWLCDGDKDC ADGADESIAA GCLYNSTCDD
REFMCQNRQC IPKHFVCDHD RDCADGSDES PECEYPTCGP SEFRCANGRC LSSRQWECDG
ENDCHDQSDE APKNPHCTSP EHKCNASSQF LCSSGRCVAE VLLCNGQDDC GDGSDERGCH
INECLSHKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADVDECSTTF PCSQRCINTH
GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV
ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD
KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSSR
SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF
EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDVP NHPCKVNNGG
CSNLCLLSPG GGHKCACPTN FYLGSDGRTC VSNCTASQFV CKNDKCIPFW WKCDTEDDCG
DHSDEPPDCP EFKCRPGQFQ CSTGICTNPA FICDGDNDCQ DNSDEANCDI HVCLPSQFKC
TNTNRCIPGI FRCNGQDNCG DGEDERDCPE VTCAPNQFQC SITKRCIPRV WVCDRDNDCV
DGSDEPANCN ERTCEPYQFR CKNNRCVPGR WQCDYDNDCG DNSDEEKVAS EEFRQGLGVP
RADRLPKDCT PRCDMDQFQC KSGHCIPLRW RCDADADCMD GSDEEACGTG VRTCPLDEFQ
CNNTLCKPLA WKCDGEDDCG DNSDENPEEC ARFVCPPNRP FRCKNDRVCL WIGRQCDGTD
NCGDGTDEED CEHPTAQTTH CKDKKEFLCR NQHCLSSSLR CNMFDDCGDG SDEEDCSIDP
KLTSCATNAS ICGDEARCVR TEKAAYCACR SGFHTVPGQP GCQDINECLR FGTCSQLCNN
TKGGHLCSCA RNFMKTHNTC KAEGSEYQVL YIADDNEIRS LFPGHPHSAY EQAFQGDESV
RIDAMDVHVK AGRVYWTNWH TGTISYRSLP PAAPPTTSNR HRRQIDRGVT HLNISGLKMP
RGIAIDWVAG NVYWTDSGRD VIEVAQMKGE NRKTLISGMI DEPHAIVVDP LRGTMYWSDW
GNHPKIETAA MDGTLRETLV QDNIQWPTGL AVDYHNERLY WADAKLSVIG SIRLNGTDPI
VAADSKRGLS HPFSIDVFED YIYGVTYINN RVFKIHKFGH SPLVNLTGGL SHASDVVLYH
QHKQPEVTNP CDRKKCEWLC LLSPSGPVCT CPNGKRLDNG TCVPVPSPTP PPDAPRPGTC
NLQCFNGGSC FLNARRQPKC RCQPRYTGDK CELDQCWEHC RNGGTCAASP SGMPTCRCPT
GFTGPKCTQQ VCAGYCANNS TCTVNQGNQP QCRCLPGFLG DRCQYRQCSG YCENFGTCQM
AADGSRQCRC TAYFEGLRCE VNKCSRCLEG VCVVNKQSGD VTCNCTDGRV APSCLTCIGH
CSNGGSCTMN SKMMPECQCP PHMTGPRCEE HVFSQQQPGH IASILIPLLL LLLVLLVAGV
VFWYKRRVQG AKGFQHQRMT NGAMNVEIGN PTYKMYEGGE PDDVGGLLDA DFALDPDKPT
NFTNPVYATL YMGGHGSRHS LASTDEKREL LGRGPEDEIG DPLA
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