ID A0A2K6QW69_RHIRO Unreviewed; 1152 AA.
AC A0A2K6QW69;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rap guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSRROP00000033037.1};
GN Name=RAPGEF6 {ECO:0000313|Ensembl:ENSRROP00000033037.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000033037.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000033037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
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DR AlphaFoldDB; A0A2K6QW69; -.
DR Ensembl; ENSRROT00000057472.1; ENSRROP00000033037.1; ENSRROG00000040103.1.
DR GeneTree; ENSGT00940000158124; -.
DR OMA; GTCEYEF; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 284..384
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 416..530
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 534..604
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 753..839
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 864..1092
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 179..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 130906 MW; DAADD472DEC0447E CRC64;
VTEPTHICGE VFDGLQARLH CTRAYGIINI SVAIFGNTVY HINASSDLNT IYSYLHGMEI
LSNLREHQLS SETIARCWYI LLSGSVLVKG SMVLPPCSFG KQFGGKRGCD CLVLEPSEMI
VVENAKDNED SILQREIPAR QSRRRFRKIN YKGERQTITD DVEVNSYLSL PADLTKMHLT
DNPHPQVTHV SSSQSGCSIA SDSGSSSLSD IYQATESEVG DVDLTRLPEG PVDSEDDEEE
DEEIDRTDPL QGRDLVRECL EKEPADKTDD DIEQLLEFMH QLPAFANMTM SVRRELCSVM
IFEVVEQAGA IILEDGQELD SWYVILNGTV EISHPDGKVE NLFMGNSFGI TPTLDKQYMH
GIVRTKVDDC QFVCIAQQDY WRILNHVEKN THKVEEEGEI VMVHEHRELD RSGTRKGHIV
IKATPERLIM HLIEEHSIVD PTYIEDFLLT YRTFLESPLD VGIKLLEWFK IDSLRDKVTR
IVLLWVNNHF NDFEGDPAMT RFLEEFEKNL EDTKMNGHLR LLNIACAAKA KWRQVVLQKA
SRESPLQFSL NGGSEKGFGI FVEVVEPGSK AADSGLKRGD QIMEVNGQNF ENITFMKALE
ILRNNTHLAL TVKTNIFVFK ELLFRTEQEK SGVPHIPKIA EKKSNRHSIQ HVPGDTEQTS
QEKGSKKVKA NTVSGGRNKI RKILDKTRFS ILPPKLFSDG GLSQSQDDSI VGTRHCRHSL
AIMPIPGTLS SSSPDLLQPT TSMLDFSNPS DIPDQVIRVF KVDQQSCYII ISKDTTAKEV
VCHAVHEFGL TGASDTYSLC EVSVTPEGVI KQRRLPDQFS KLADRIQLNG RYYLKNNMET
ETLCSDEDAQ ELVKESQLSM LQLSTIEVAT QLSMRDFDLF RNIEPTEYID DLFKLNSKTG
NTHLKRFEDI VNQETFWVAS EILTEANQLK RMKIIKHFIK IALHCRECKN FNSMFAIISG
LNLASVARLR GTWEKLPSKY EKHLQDLQDI FDPSRNMAKY RNILSSQSMQ PPIIPLFPVV
KKDMTFLHEG NDSKVDGLVN FEKLRMISKE IRQVVRMTSA NMDPAMMFRQ RSLSQGSTNS
NMLDVQGGAH KKRARRSSLL NAKKLYEDAQ MARKVKQYLS SLDVETDEEK FQMMSLQWEP
AYGTCEYEFS FM
//