ID A0A2K6QWQ9_RHIRO Unreviewed; 540 AA.
AC A0A2K6QWQ9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN Name=TKTL1 {ECO:0000313|Ensembl:ENSRROP00000033232.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000033232.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000033232.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR AlphaFoldDB; A0A2K6QWQ9; -.
DR STRING; 61622.ENSRROP00000033232; -.
DR Ensembl; ENSRROT00000057669.1; ENSRROP00000033232.1; ENSRROG00000040219.1.
DR GeneTree; ENSGT00940000162426; -.
DR OMA; NSGHSGM; -.
DR OrthoDB; 178912at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR020826; Transketolase_BS.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR PANTHER; PTHR43195:SF2; TRANSKETOLASE-LIKE PROTEIN 1; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 233..397
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 540 AA; 59378 MW; 263B71232018AD48 CRC64;
MSVLFFYIMR YKQSDPENPD NDRFVLAKRL SFVDVATGWL GQGLGVACGM AYTGKYFDRA
SYRVFCLMSD GESSEGSVWE AMAFASYYGL DNLVAIFDVN RLGHSGALPA EHCIDIYQRR
CEAFGWNTYV VDGRDVEALC QVFWQASQVK HKPTAVVAKT FKGRGTPSIE DAESWHGKPM
PRERADAIIK LIESQIETSR SLDPQLPIED SPEVNITDVR MISPPDYRVG DKIATRRACG
LALAKLGYAN DRVIVLDGDT KYSTFSEIFN KEYPERFIEC FMAEQNMVSV ALGCASRGRT
IAFASTFAAF LTRAFDQIRI GGLSESNINI IGSHCGVSVG EDGASQMALE DIAMFRTIPK
CTIFYPTDAV STEHAVSLAA NTKGICFIRT TRPETMVIYT PQERFEIGQA KVLRHCVSDK
VTVIGAGITV YEALAAADEL LKQDIFIRVI DLFTIKPLDV TTIISSAKAT EGRIITVEDH
YPQGGIGEAV CAAVSMDPDI QVHSLAVSGV PQSGKSEELL DMYGISARHI IVAVKCILLN
//