ID A0A2K6QXI4_RHIRO Unreviewed; 2442 AA.
AC A0A2K6QXI4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
GN Name=ACACB {ECO:0000313|Ensembl:ENSRROP00000033441.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000033441.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000033441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001448};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11309;
CC Evidence={ECO:0000256|ARBA:ARBA00001448};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR STRING; 61622.ENSRROP00000033441; -.
DR Ensembl; ENSRROT00000057879.1; ENSRROP00000033441.1; ENSRROG00000040293.1.
DR GeneTree; ENSGT00940000155049; -.
DR OMA; TEHCKVA; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0060421; P:positive regulation of heart growth; IEA:Ensembl.
DR GO; GO:0010884; P:positive regulation of lipid storage; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF1; ACETYL-COA CARBOXYLASE 2; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 243..745
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 402..593
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 872..946
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1679..2009
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 2013..2329
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2442 AA; 275600 MW; 371A4D17864FAB23 CRC64;
FXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXPSMSGLHL VKRGREHKKL DLHRDFTVAS PAEFVTRFGG
DRVIEKVLIA NNGIAAVKCM RSIRRWAYEM FRNERAIRFV VMVTPEDLKA NAEYIKMADQ
YVPVPGGPNN NNYANVELIV DIAKRIPVQA VWAGWGHASE NPKLPELLCK NGVAFLGPPS
EAMWALGDKI ASTIVAQTLQ VPTLPWSGSG LTVEWTEDDL QQGKIISVPE DVYDQGCVKD
VDEGLEAAEK IGFPLMIKAS EGGGGKGIRK AESAEDFPIL FRQVQSEIPG SPIFLMKLAQ
HARHLEVQIL ADQYGNAVSL FGRDCSIQRR HQKIVEEAPA TIAPLAIFEF MEQCAVRLAK
TVGYVSAGTV EYLYSQDGSF HFLELNPRLQ VEHPCTEMIA DVNLPAAQLQ IAMGVPLHRL
KDIRLLYGES PWGVTPISFE TPSNPPLARG HVIAARITSE NPDEGFKPSS GTVQELNFRS
SKNVWGYFSV AATGGLHEFA DSQFGHCFSW GENREEAISN MVVALKELSI RGDFRTTVEY
LINLLETESF QNNDIDTGWL DYLIAEKVQA EKPDIMLGVV CGALNVADAM FRTCMTDFLH
SLERGQVLPA DSLLNIVDVE LIYGGIKYIL KVARQSLTMF VLIMNGCHIE IDAHRLNDGG
LLLSYNGNSY TTYMKEEVDS YRITIGNKTC VFEKENDPTV LRSPSAGKLT QYTVEDGGHV
EAGSSYAEME VMKMIMTLNV QESGRVKYIK RPGAVLEAGC VVARLELDDP SKVHPAEPFT
GELPAQQTLP ILGEKLHQVF HSVLENLTNV MSGFCLPEPI FSIKLKEWVQ KLMMTLRHPS
LPLLELQEIM TSVAGRIPAP VEKSVRRVMA QYASNITSVL CQFPSQQIAT ILDCHAATLQ
RKADREVFFI NTQSIVQLVQ RYRSGIRGYM KTVVLDLLRR YLHVEHHFQQ AHYDKCVINL
REQFKPDMSQ VLDCIFSHAQ VAKKNQLVIM LIDELCGPDP SLSDELTSIL NELTQLSKSE
HCKVALRARQ ILIASHLPSY ELRHNQVESI FLSAIDMYGH QFCPENLKKL IISETTIFDV
LPAFFYHANK VVCMASLEVY VRRGYIAYEL NSLQHRQLPD GTCVVEFQFM LPSSHPNRMT
VPISITNPDL LRHSTELFMD SGFSPLCQRM GAMVAFRRFE DFTRNFDEVI SCFANVPKDT
PLFSEARTSL YSEDDCKSLR EDPIHILNVS IQCADHLEDE ELVPILRTFV QSKKNILVDY
GLRRITFLIA QEKEFPKFFT FRARDEFAED RIYRHLEPAL AFQLELSRMR NFDLTAVPCA
NHKMHLYLGA AKVKEGAEVT DHRFFIRAII RHSDLITKEA SFEYLQNEGE RLLLEAMDEL
EVAFNNTSVR TDCNHIFLNF VPTVIMDPLK IEESVRSMVM RYGSRLWKLR VLQAEVKINI
HQTTTGSAVP IRLFITNESG YYLDISLYKE VTDSRSGNIM FHSFGNKQGP QHGMLINTPY
VTKDLLQAKR FQAQSLGTTY IYDFPEIFRQ ALFKLWGSPD KYPKDILTYT ELVLDSQGQL
VEMNRLPGGN EVGMVAFKMR FKTQEYPEGR DMIVIGNDIT FRIGSFGPGE DLLYLRASEM
ARALGIPKIY VAANSGARIG MAEEIKHMFH VAWVDPEDPH KGFKYLYLTP QDYTRISSLN
SVHCKHIEEG GESRYMITDI IGKDDGLGVE NLRGSGMIAG ESSLAYEEIV TISLVTCRAL
GIGAYLVRLG QRVIQVENSH IILTGASALN KVLGREVYTS NNQLGGVQIM HYNGVSHITV
PDDFEGVYTI LEWLSYMPKD NHSPVPIITP TDPIDREIEF LPSRAPYDPR WMLAGRPHPT
LKGTWQSGFF DHGSFKEIMA PWAQTVVTGR ARLGGIPVGV IAVETRTVEV AVPADPANLD
SEAKIIQQAG QVWFPDSAYK TAQAIKDFNR EKLPLMIFAN WRGFSGGMKD MYDQVLKFGA
YIVDGLRQYK QPILIYIPPY AELRGGSWVV IDATINPLCI EMYADKESRG GVLEPEGTVE
IKFRKKDLIK SMRRIDPAYK KLMEQLGEPD LSDKDRKDLE GRLKAREDLL LPIYHQVAVQ
FADFHDTPGR MLEKGVISDI LEWKTARTFL YWRLRRLLLE DQVKQEILRA SGELSHVHIQ
SMLRRWFVET EGAVKAYLWD NNQVVVQWLE QHWQVEDGPR STIRENITYL KHDSVLKTIR
GLVQENPEVA VDCVIYLSQH ISPAERAQVI HLLSTMDSPA ST
//
