ID   A0A2K6R0A2_RHIRO        Unreviewed;      1137 AA.
AC   A0A2K6R0A2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=AP-4 complex subunit epsilon {ECO:0000256|PIRNR:PIRNR037097};
GN   Name=AP4E1 {ECO:0000313|Ensembl:ENSRROP00000034477.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000034477.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000034477.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor
CC       protein complexes are vesicle coat components involved both in vesicle
CC       formation and cargo selection. They control the vesicular transport of
CC       proteins in different trafficking pathways. AP-4 forms a non clathrin-
CC       associated coat on vesicles departing the trans-Golgi network (TGN) and
CC       may be involved in the targeting of proteins from the trans-Golgi
CC       network (TGN) to the endosomal-lysosomal system.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
CC   -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC       of two large adaptins, a medium adaptin and a small adaptin.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
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DR   RefSeq; XP_010354901.1; XM_010356599.1.
DR   AlphaFoldDB; A0A2K6R0A2; -.
DR   STRING; 61622.ENSRROP00000034477; -.
DR   Ensembl; ENSRROT00000058923.1; ENSRROP00000034477.1; ENSRROG00000040786.1.
DR   GeneID; 104656902; -.
DR   KEGG; rro:104656902; -.
DR   CTD; 23431; -.
DR   GeneTree; ENSGT00950000182838; -.
DR   OrthoDB; 25313at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0030124; C:AP-4 adaptor complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR017109; AP4_complex_esu.
DR   InterPro; IPR028269; AP4E1_C.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR   PANTHER; PTHR22780:SF13; AP-4 COMPLEX SUBUNIT EPSILON-1; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF14807; AP4E_app_platf; 1.
DR   PIRSF; PIRSF037097; AP4_complex_epsilon; 1.
DR   SMART; SM01356; AP4E_app_platf; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR037097};
KW   Membrane {ECO:0000256|PIRNR:PIRNR037097};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR037097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037097}.
FT   DOMAIN          1032..1135
FT                   /note="AP-4 complex subunit epsilon-1 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01356"
FT   REGION          717..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1137 AA;  127402 MW;  E26DFF8411D679DD CRC64;
     MSDIVEKTLT ALPGLFLQNQ PGGGPAAAKA SFSSRLGSLV RGITALTSKH EEEKLIQQEL
     SSLKATVSAP TTTLKMMKEC MVRLIYCEML GYDASFGYIH AIKLAQQGNL LEKRVGYLAV
     SLFLHESHEL LLLLVNTVVK DLQSTNLVEV CMALTVVSQI FPREMIPAVL PLIEDKLQHS
     KEIIRRKAVL ALYKFHLIAP NQVQHIHIKF RKALCDRDVG VMAASLHIYL RMIKENSSGY
     KDLTGSFVTI LKQVVGGKLP VDFNYHSVPA PWLQIQLLRI LGLLGKDDQR TSELMYDVLD
     ESLRRAELNH NVTYAILFEC VHTVYSIYPK SELLEKAAKC IGKFVLSPKI NLKYLGLKAL
     TYVIQQDPTL ALQHQMTIIE CLDHPDPIIK RETLELLYRI TNAQNVTVIV QKMLEYLHQS
     KEEYVIVNLV GKIAELAEKY APDNAWFIQT MNAVFSVGGD VMHPDIPNNF LRLLAEGFDD
     ETEDQQLRLY AVQSYLTLLD MENVFYPQRF LQVMSWVLGE YSYLLDKETP AEVIAKLYKL
     LMNDSVSSET KTWLIAAVTK LTPQAHSSDT VERLIHEFTI SLDTCMRQHA FELKHLHENV
     ELMTSLLPVD RSCEDLAVDA SLSFLDGFVA EGLSQGAAPY KPHHQRQEEK LSQEKVLNFE
     PYGLSFSSSG FTGRQSPAGI SLGSDISGNS AETGLKETNS LKLEGIKKLW GKEGYLPKKE
     SKTGDESGAL PIPQESIMEN VDQTITKKDQ SQVLTQSKEE KEKQLLASSL FVGLGSESTV
     NLLGKADTVS HKFRRKSKIK EAKSGEASST HNMTCSSFSS LSNVAYEDDY YLNTLHDRGD
     KELKTFSLNS ELLDSESLTE LPLVEKFSNC SLSTPSLFAD NSMEIFHPPQ SIAASVAKES
     SLASSFLEET TEYIHSNAME VCNNETISVS SYKIWKDDCL LMVWSVTNKS GLELKSANLE
     IFPAENFKVT EQPGCCLPIM EAESTKSFQY SVQIEKPFTE GILSGFIRYH MMDTHSAQLE
     FSVNLSLLDF IRPLKISSED FGKLWLSFAN DVKQNVKMSE SQAALPSALK TLQQKLRLHI
     IEIIGNEGLL ACQLLPSIPC LLHCRVYADV LALWFRSSCS TLPDYLLYQC QKVIEGS
//