ID A0A2K6R104_RHIRO Unreviewed; 428 AA.
AC A0A2K6R104;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 13 {ECO:0000313|Ensembl:ENSRROP00000034718.1};
GN Name=ADAMTS13 {ECO:0000313|Ensembl:ENSRROP00000034718.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000034718.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000034718.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6R104; -.
DR Ensembl; ENSRROT00000059167.1; ENSRROP00000034718.1; ENSRROG00000040887.1.
DR GeneTree; ENSGT00940000158379; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF20; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|PIRSR:PIRSR613273-2};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR613273-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 41..115
FT /note="ADAM cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM00608"
FT REGION 21..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 22
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT DISULFID 52..78
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 63..88
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 73..107
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 101..112
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 137..174
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 141..179
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 152..164
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 428 AA; 46261 MW; 24A49E0EF0A9C94D CRC64;
MASDGAAPRA AGPCRSAGRA RCVWDPPRPQ PGSTGRPPEA QPGLYYSANE QCRVAFGPKA
VACTFAREHL DICQALSCHT DPLDQSSCSR LLVPLLDGTE CGVEKWCSKG RCRSLVELTP
IAAVHGHWSS WGPQSPCSRS CGGGVVTRRR QCNNPRPAFG GRACVGADLQ AEMCNTQACE
KTQLEFMSEQ CARTDGQPLH SSPGGASFYH WGAAVPHSQG DALCRHMCRA IGENFIMKRG
DSFLDGTRCV PSGSREDGTL SLCVSGSCRT FGCDGRMDSQ QVRDVCQVCG GDNSTCSPRN
GSFTAGRVRE YVTFLTVTPN LTSVYIANHR PLFTHLAVRI GGRYVVAGKT SISPNTIYPS
LLEDGRVEYR VALTEDRLPR LEEIHIWGPL QEDAEIQVGD VRAQPMHISQ WSRPDLCAGG
RWPGGSSD
//