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Database: UniProt
Entry: A0A2K6R104_RHIRO
LinkDB: A0A2K6R104_RHIRO
Original site: A0A2K6R104_RHIRO 
ID   A0A2K6R104_RHIRO        Unreviewed;       428 AA.
AC   A0A2K6R104;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 13 {ECO:0000313|Ensembl:ENSRROP00000034718.1};
GN   Name=ADAMTS13 {ECO:0000313|Ensembl:ENSRROP00000034718.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000034718.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000034718.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6R104; -.
DR   Ensembl; ENSRROT00000059167.1; ENSRROP00000034718.1; ENSRROG00000040887.1.
DR   GeneTree; ENSGT00940000158379; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 3.40.1620.60; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR041645; ADAMTS_CR_2.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723:SF20; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13; 1.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   Pfam; PF17771; ADAMTS_CR_2; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR613273-2};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR613273-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR613273-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          41..115
FT                   /note="ADAM cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM00608"
FT   REGION          21..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         22
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT   BINDING         25
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT   BINDING         25
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT   DISULFID        52..78
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        63..88
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        73..107
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        101..112
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        137..174
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        141..179
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        152..164
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ   SEQUENCE   428 AA;  46261 MW;  24A49E0EF0A9C94D CRC64;
     MASDGAAPRA AGPCRSAGRA RCVWDPPRPQ PGSTGRPPEA QPGLYYSANE QCRVAFGPKA
     VACTFAREHL DICQALSCHT DPLDQSSCSR LLVPLLDGTE CGVEKWCSKG RCRSLVELTP
     IAAVHGHWSS WGPQSPCSRS CGGGVVTRRR QCNNPRPAFG GRACVGADLQ AEMCNTQACE
     KTQLEFMSEQ CARTDGQPLH SSPGGASFYH WGAAVPHSQG DALCRHMCRA IGENFIMKRG
     DSFLDGTRCV PSGSREDGTL SLCVSGSCRT FGCDGRMDSQ QVRDVCQVCG GDNSTCSPRN
     GSFTAGRVRE YVTFLTVTPN LTSVYIANHR PLFTHLAVRI GGRYVVAGKT SISPNTIYPS
     LLEDGRVEYR VALTEDRLPR LEEIHIWGPL QEDAEIQVGD VRAQPMHISQ WSRPDLCAGG
     RWPGGSSD
//
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