ID A0A2K6R2F6_RHIRO Unreviewed; 404 AA.
AC A0A2K6R2F6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Corticosteroid-binding globulin {ECO:0000256|ARBA:ARBA00039186};
DE AltName: Full=Serpin A6 {ECO:0000256|ARBA:ARBA00043180};
DE AltName: Full=Transcortin {ECO:0000256|ARBA:ARBA00041777};
GN Name=SERPINA6 {ECO:0000313|Ensembl:ENSRROP00000035189.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000035189.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000035189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Major transport protein for glucocorticoids and progestins in
CC the blood of almost all vertebrate species.
CC {ECO:0000256|ARBA:ARBA00037222}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR RefSeq; XP_010382843.1; XM_010384541.1.
DR AlphaFoldDB; A0A2K6R2F6; -.
DR STRING; 61622.ENSRROP00000035189; -.
DR Ensembl; ENSRROT00000059642.1; ENSRROP00000035189.1; ENSRROG00000041104.1.
DR GeneID; 104679068; -.
DR KEGG; rro:104679068; -.
DR CTD; 866; -.
DR GeneTree; ENSGT00940000161611; -.
DR OMA; HDSELPC; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
DR CDD; cd19554; serpinA6_CBG; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF34; CORTICOSTEROID-BINDING GLOBULIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR PRINTS; PR00780; LEUSERPINII.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..404
FT /note="Corticosteroid-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014321310"
FT DOMAIN 48..403
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 404 AA; 44718 MW; 8BC58822573B435F CRC64;
MPLLPYTCLL WLSTSGLWTV QAMDPNAAYR NMSNHHRGLA SVNADFALSL YKHLVALSPK
KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAESD
TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF RDWATASRQI NSYVKSKTQG
KIADLLSGLD SPAVLVLVNY IFFKGTWTQH FDLASTGENF YVDETTVVKV PMMFQSSTIS
YLHDSELPCQ LVQLNYVGNG TVFFILPDKG KMNTVIAALS RDTINRWSAG LTNSQVDLYI
PKVTISGVYD LGDVLEEMGI ADLFTNQANF SGITQDAQLK SSKVVHKAVL QLSEEGVDTA
GSTGVSLNLT SKPIILRFNQ PFIIMIFDHF TWSSLFLARV VNPA
//
