ID A0A2K6R3L3_RHIRO Unreviewed; 372 AA.
AC A0A2K6R3L3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cellular communication network factor 6 {ECO:0000313|Ensembl:ENSRROP00000035604.1};
GN Name=CCN6 {ECO:0000313|Ensembl:ENSRROP00000035604.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000035604.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000035604.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010358188.1; XM_010359886.1.
DR AlphaFoldDB; A0A2K6R3L3; -.
DR STRING; 61622.ENSRROP00000035604; -.
DR Ensembl; ENSRROT00000060062.1; ENSRROP00000035604.1; ENSRROG00000041294.1.
DR GeneID; 104659764; -.
DR KEGG; rro:104659764; -.
DR CTD; 8838; -.
DR GeneTree; ENSGT00940000160119; -.
DR OrthoDB; 2970572at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR11348:SF3; CELLULAR COMMUNICATION NETWORK FACTOR 6; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..372
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014326407"
FT DOMAIN 62..135
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 286..360
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 372 AA; 41530 MW; 93F1A49CD3A13FE8 CRC64;
MNKRRLLYPS GWLHGPSDMR GLLFSTLLLA GLAQFCCRTQ GTGPLDTTPE GRPGEVSDAH
QRKQFCHWPC KCPHQKPHCP PGVSLVRDGC GCCKICAKQP GEICNEADLC DPHKGLYCDY
SVDRPRYETG VCAYLVAVGC EFNQVHYYNG QVFQPNPLFS CLCVSGAIGC TPLFIPKLAD
SHCSGAKGGK KSDQSNCGLE PLLQQLSTSY KTMPAYRNLP LIWKKKCLVQ ATKWTPCSRT
CGMGISNRVT NENSNCEMRK EKRLCYIQPC DSKILKTIKI PKGKTCQPTF QLSKAEKFVF
SGCSSTQSYK PTFCGICLDK RCCIPNKSKM ITIQFDCPNE GSFKWKMLWI TSCVCQRNCR
EPGDIFSELK IL
//