ID A0A2K6R478_RHIRO Unreviewed; 344 AA.
AC A0A2K6R478;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Growth differentiation factor 11 {ECO:0000313|Ensembl:ENSRROP00000035827.1};
GN Name=GDF11 {ECO:0000313|Ensembl:ENSRROP00000035827.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000035827.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000035827.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A2K6R478; -.
DR STRING; 61622.ENSRROP00000035827; -.
DR Ensembl; ENSRROT00000060285.1; ENSRROP00000035827.1; ENSRROG00000041390.1.
DR GeneTree; ENSGT00940000161052; -.
DR OMA; SPHCCHF; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:1902870; P:negative regulation of amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0021512; P:spinal cord anterior/posterior patterning; IEA:Ensembl.
DR GO; GO:0072560; P:type B pancreatic cell maturation; IEA:Ensembl.
DR GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR CDD; cd19388; TGF_beta_GDF8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF166; GROWTH_DIFFERENTIATION FACTOR 11; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 232..344
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 344 AA; 39149 MW; 2514704EFA7D6D67 CRC64;
VCVWRQHSRE LRLESIKSQI LSKLRLKEAP NISREVVKQL LPKAPPLQQI LDLHDFQGDA
LQPEDFLEED EYHATTETVI SMAQETDPAV QTDGSPLCCH FHFSPKVMFT KVLKAQLWVY
LRPVPRPATV YLQILRLKPL TGEGTAGGGG GGRRHIRIRS LKIELHSRSG HWQSIDFKQV
LHSWFRQPQS NWGIEINAFD PSGTDLAVTS LGPGAEGLHP FMELRVLENT KRSRRNLGLD
CDEHSSESRC CRYPLTVDFE AFGWDWIIAP KRYKANYCSG QCEYMFMQKY PHTHLVQQAN
PRGSAGPCCT PTKMSPINML YFNDKQQIIY GKIPGMVVDR CGCS
//
