ID A0A2K6R6B7_RHIRO Unreviewed; 408 AA.
AC A0A2K6R6B7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Apolipoprotein A-IV {ECO:0000256|ARBA:ARBA00041197};
DE AltName: Full=Apolipoprotein A4 {ECO:0000256|ARBA:ARBA00042591};
GN Name=APOA4 {ECO:0000313|Ensembl:ENSRROP00000036567.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000036567.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000036567.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC catabolism. Required for efficient activation of lipoprotein lipase by
CC ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL
CC and chylomicrons. {ECO:0000256|ARBA:ARBA00037735}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR RefSeq; XP_010370007.1; XM_010371705.1.
DR AlphaFoldDB; A0A2K6R6B7; -.
DR STRING; 61622.ENSRROP00000036567; -.
DR Ensembl; ENSRROT00000061030.1; ENSRROP00000036567.1; ENSRROG00000041743.1.
DR GeneTree; ENSGT00950000182929; -.
DR OMA; VIWKYFT; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0042627; C:chylomicron; IEA:Ensembl.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0016209; F:antioxidant activity; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:Ensembl.
DR GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0016042; P:lipid catabolic process; IEA:Ensembl.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0034445; P:negative regulation of plasma lipoprotein oxidation; IEA:Ensembl.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:Ensembl.
DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0065005; P:protein-lipid complex assembly; IEA:Ensembl.
DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
DR GO; GO:0019430; P:removal of superoxide radicals; IEA:Ensembl.
DR GO; GO:0006982; P:response to lipid hydroperoxide; IEA:Ensembl.
DR GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF1; APOLIPOPROTEIN A-IV; 1.
DR Pfam; PF01442; Apolipoprotein; 2.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; HDL {ECO:0000256|ARBA:ARBA00022850};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..408
FT /note="Apolipoprotein A-IV"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014467886"
FT REGION 360..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 235..266
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 373..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 47168 MW; C3611B628D230765 CRC64;
MFLKAVVLTL ALVAVTGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ KSELTQQLNA
LFQDKLGEVN TYADDLQKKL VPFATELHER LAKDSEKLKE EIRKELEEVR ARLLPHANEV
SQKIGENVRE LQQRLEPYTD QLRTQVNTQT EQLRRQLTPY AQRMERVLRE NAHSLQASLR
PHADQLKAKI DQNVEELKER LTPYADEFKV KIDQTVEELR RSLAPYAQDA QEKLNHQLEG
LAFQMKKNAE ELRARISASA EELRQRLAPL AEDMRGNLRG NTEGLQKSLA ELGGHLDQHV
EEFRLRVEPY GENFNKALVQ QLEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE
KESQDKTLSL PKPKQQEEQV QEQQQEQQQE QQQEQQQEQV QMLAPLES
//
