ID   A0A2K6R7M0_RHIRO        Unreviewed;       665 AA.
AC   A0A2K6R7M0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN   Name=PREPL {ECO:0000313|Ensembl:ENSRROP00000037027.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000037027.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000037027.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000256|ARBA:ARBA00004601}.
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   AlphaFoldDB; A0A2K6R7M0; -.
DR   Ensembl; ENSRROT00000061495.1; ENSRROP00000037027.1; ENSRROG00000041940.1.
DR   GeneTree; ENSGT00530000063426; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR11757:SF19; PROLYL ENDOPEPTIDASE-LIKE; 1.
DR   PANTHER; PTHR11757; PROTEASE FAMILY S9A OLIGOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU368024};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          108..317
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          428..642
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   665 AA;  76846 MW;  BD90A8204517E9BB CRC64;
     MQQKTKLFLQ ALKYSIPHLG KCMQKQHLNH YNFADHYYNR IKLKKYHLTK CLQNKPKISE
     LARNIPSRSF SCKDLQPVKQ ENEKPLPENM DAFEKVRTKL ETQPQEEYEI INVEVKHGGF
     VYYQEGCCLV RSKDEEADND NYEVLFNLEE LKLDQPFIDC IRVAPDEKYV AAKIRTEDSE
     ASTCVIIKLS DQPVMEVSFP NVSSFEWVKD EEDEDVLFYT FQRNLRCHDV YRATFGDNKR
     NERFYTEKDP SYFVFLYLTK DSRFLTINIM NKTTSEVWLI DGLSPWDPPV LIQKRIHGVL
     YYVEHRDDEL YILTNVGEPT EFKLPPWACG FIMDTNSDPK NCPFQLCSPI RPPKYYTYKF
     AEGKLFEETG HEDPITKTSR VLRLEAKSKD GKLVPMTVFH KTDSEDLQKK PLLIHVYGAY
     GMDLKMNFRP ERRVLVDDGW ILAYCHVRGG GELGLQWHAD GRLTKKLNGL ADLEACIKTL
     HGQGFSQPSL TTLTAFSAGG VLAGALCNSN PELLRAVTLE APFLDVLNTM MDTTLPLTLE
     ELEEWGNPSS DEKHKNYIKR YCPYQNIKPQ HYPSVHITAY ENDERVPLKG IVSYTEKLKE
     AISEHAKDTG EGYQAPNIIL DIQPGGNHVI EDSHKKITAQ IKFLYEELGL DSTSVFEDLK
     KYLKF
//