ID   A0A2K6R9G2_RHIRO        Unreviewed;       252 AA.
AC   A0A2K6R9G2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000037682.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000037682.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   AlphaFoldDB; A0A2K6R9G2; -.
DR   Ensembl; ENSRROT00000062154.1; ENSRROP00000037682.1; ENSRROG00000042225.1.
DR   GeneTree; ENSGT00950000183113; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          2..249
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   252 AA;  28141 MW;  292A5D9AA216F09E CRC64;
     QKLHVHLDGA IKPETILYYG RRRGIALPAN TAEGLLNVIG MDKPLTLPDF LAKFDYYMPA
     IAGCREAIKR IAYEFIEMKA KEGVVYVEVR YSPHLLANSK VEPIPWNQAE GDLTPDEVVA
     LVGQGLQEGE RDFGVKARSI LCCMRHQPNW SPEVVELCKK YQQQTVVAID LAGDETIPGS
     SLLPGHVQAY QEAVKSGIHR TVHAGEVGSA EVVKEAVDIL KTERLGHGYH TLEDQALYDR
     LRQENMHFEA QK
//