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Database: UniProt
Entry: A0A2K6R9X2_RHIRO
LinkDB: A0A2K6R9X2_RHIRO
Original site: A0A2K6R9X2_RHIRO 
ID   A0A2K6R9X2_RHIRO        Unreviewed;       130 AA.
AC   A0A2K6R9X2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 1 {ECO:0000313|Ensembl:ENSRROP00000037839.1};
GN   Name=GDPD1 {ECO:0000313|Ensembl:ENSRROP00000037839.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000037839.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000037839.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-
CC         ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate +
CC         H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53184,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464,
CC         ChEBI:CHEBI:137009, ChEBI:CHEBI:137017;
CC         Evidence={ECO:0000256|ARBA:ARBA00036725};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53185;
CC         Evidence={ECO:0000256|ARBA:ARBA00036725};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-
CC         hexadecyl-sn-glycero-3-phosphate + choline + H(+);
CC         Xref=Rhea:RHEA:41143, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:64496, ChEBI:CHEBI:77580;
CC         Evidence={ECO:0000256|ARBA:ARBA00036083};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41144;
CC         Evidence={ECO:0000256|ARBA:ARBA00036083};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-
CC         phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate +
CC         H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:56460,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466,
CC         ChEBI:CHEBI:74544, ChEBI:CHEBI:85222;
CC         Evidence={ECO:0000256|ARBA:ARBA00035902};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56461;
CC         Evidence={ECO:0000256|ARBA:ARBA00035902};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-
CC         sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC         phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine;
CC         Xref=Rhea:RHEA:45544, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:74544, ChEBI:CHEBI:85223;
CC         Evidence={ECO:0000256|ARBA:ARBA00023561};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45545;
CC         Evidence={ECO:0000256|ARBA:ARBA00023561};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-
CC         phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate +
CC         H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:53168,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464,
CC         ChEBI:CHEBI:74544, ChEBI:CHEBI:85217;
CC         Evidence={ECO:0000256|ARBA:ARBA00036780};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53169;
CC         Evidence={ECO:0000256|ARBA:ARBA00036780};
CC   -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC       family. {ECO:0000256|ARBA:ARBA00007277}.
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DR   AlphaFoldDB; A0A2K6R9X2; -.
DR   Ensembl; ENSRROT00000062311.1; ENSRROP00000037839.1; ENSRROG00000042332.1.
DR   GeneTree; ENSGT00940000156673; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR   InterPro; IPR030395; GP_PDE_dom.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   PANTHER; PTHR42758:SF1; LYSOPHOSPHOLIPASE D GDPD1; 1.
DR   PANTHER; PTHR42758; PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C; 1.
DR   Pfam; PF03009; GDPD; 1.
DR   SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR   PROSITE; PS51704; GP_PDE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..130
FT                   /note="GP-PDE"
FT                   /evidence="ECO:0000259|PROSITE:PS51704"
SQ   SEQUENCE   130 AA;  14576 MW;  5F1DACCA4B1028D8 CRC64;
     MSSTAAFYLL STLGGYLVTS FLLLKYPTLL HQRKKQRFLS KHISHRGGAG ENLENTMAAF
     QHAVKIGTDM LELDCHITKD EQVVVSHDEN LKRATGVNVN ISDLKYCELP PYLGKLDVSF
     QRARCGDVHL
//
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