ID A0A2K6RA53_RHIRO Unreviewed; 1453 AA.
AC A0A2K6RA53;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear factor of activated T cells 5 {ECO:0000313|Ensembl:ENSRROP00000037918.1};
GN Name=NFAT5 {ECO:0000313|Ensembl:ENSRROP00000037918.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000037918.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000037918.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010353722.1; XM_010355420.1.
DR Ensembl; ENSRROT00000062390.1; ENSRROP00000037918.1; ENSRROG00000042350.1.
DR GeneTree; ENSGT00940000155213; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 188..367
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 40..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 157705 MW; 026843BFF7444907 CRC64;
MGGACSSFTT SSSPTIYSTS VTDSKAMQVE SCSSAVGVSN RGVSEKQLTS NTVQQHPSTP
KRHTVLYISP PPEDLLDNSR MSCQDEGCGL ESEQSCSMWM EDSPSNFSNM STSSYNDNTE
VPRKSRKRNP KQRPGVKRRD CEESNMDIFD ADSAKAPHYV LSQLTTDNKG NSKAGNGTLE
NQKGTGVKKS PMLCGQYPVK SEGKELKIVV QPETQHRARY LTEGSRGSVK DRTQQGFPTV
KLEGHNEPVV LQVFVGNDSG RVKPHGFYQA CRVTGRNTTP CKEVDIEGTT VIEVGLDPSN
NMTLAVDCVG ILKLRNADVE ARIGIAGSKK KSTRARLVFR VNITRKDGST LTLQTPSSPI
LCTQPAGVPE ILKKSLHSCS VKGEEEVFLI GKNFLKGTKV IFQENVSDEN SWKSEAEIDM
ELFHQNHLIV KVPPYHDQHI TLPVSVGIYV VTNAGRSHDV QPFTYTPDPA AAGALNVNVK
KEVSSPARPC SFEEAMKAMK TTGCNLDKVN IIPNALITPL IPSSMIKSED VTPMEVTAEK
RSSTIFKTTK TVGSTQQALE NISNIAGNGS FSSPSSSHLP SENEKQQQIQ PKAYNPETLT
TIQTQDISQP GTFPAVSASS QLPNSEALLQ QATQFQTRES QSREVLQSDG TVVNLSQLTE
ASQQQQQSPL QEQAQTLQQQ ISSNIFPSPN SVSQLQNTIQ QLQAGSFTGS TASGSSGSVD
LVQQVLEAQQ QLSSVLFSAP DGNENVQEQL SADIFQQVSQ IQSGVSPGMF SSTEPTVHTR
PDNLLPGRAE SVHPQSENTL SNQQQQQQQQ QVMESSAAMV MEMQQSICQA AAQIQSELFP
STASANGNLQ QSPVYQQTSH MMSALSTNED MQMQCELFSS PPAVSGNETS TTTTQQVATP
GTTMFQTSSS GDGEETGTQA KQIQNSVFQT MVQMQHSGDN QPQVNLFSST KSMMSVQNST
QQQGNGLFQQ GNEMMSLQSG NFLQQSSHSQ AQLFHPQNPI ADTQNLSQET QGSLFHSPNP
IVHSQTSTTS SEQMQPPMFH SQSTIAVLQG SSVPQDQQST NIFLSQSPMN NLQTNTVAQE
AFFAAPNSIS PLQSTSNTEQ QAAFQQQAPI SHIQTPMLSQ EQAQPPQQGL FQPQVSLGSL
PPNPMPQSQQ GTMFQSQHSI VAMQSNSPSQ EQQQQQQQQQ QQQQQQQQGI LFSNQNTMAT
MASPKQPPPN MIFNPNQNPM ANQEQQNQSI FHQQSNMAPM NQEQQPMQFQ SQSTVSSLQN
PGPTQSESSQ TPLFHSSPQI QLVQGSPSSQ EQQVTLFLSP ASMSALQTSI NQQDMQQSPL
YSPQNNMPGI QGATSSPQPQ ATLFHNTAGG TMNQLQNSPG SSQQASGMFL FGIQNNCSQL
LTSGPATLPD QLMAISQPGQ PQNEGQPPVT TLLSQQMPEN SPLASSINTN QNIEKIDLLV
SLQNQGNNLT GSF
//
