ID A0A2K6RDF9_RHIRO Unreviewed; 2504 AA.
AC A0A2K6RDF9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear receptor corepressor 2 {ECO:0000313|Ensembl:ENSRROP00000039083.1};
GN Name=NCOR2 {ECO:0000313|Ensembl:ENSRROP00000039083.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000039083.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000039083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR Ensembl; ENSRROT00000063560.1; ENSRROP00000039083.1; ENSRROG00000042597.1.
DR GeneTree; ENSGT00940000159022; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 426..477
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 606..657
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 609..653
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 610..657
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 121..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1927..2016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2030..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2164..2225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2238..2259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2374..2490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..717
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..987
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1778..1803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2415..2429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2504 AA; 272928 MW; 9889EC0AB94C5001 CRC64;
MSGSTQPVAQ TWRATETRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA SHLSPGSIIQ
PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM EFIESKRPRL ELLPDPLLRP
SPLLAAGQPA GSEDLTKDRS LTGKLEPVSP PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QRVGQRGSGL
SMSAARSEHE VSEIIDGLSE QENLEKQMRQ LAVIPPMLYD ADQQRIKFIN MNGLMADPMK
VYKDRQVMNM WSEQEKETFR EKFMQHPKNF GLIASFLERK TVAECVLYYY LTKKNENYKS
LVRRSYRRRG KSQQQQQQQQ QQQQQQPMPR SSQEEKDEKE KEKEAEKEEE KPEVENDKED
LLKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANSEE AITPQQSAEL
ASMELNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE
ILQQHKLKME KERNARRKKK KAPAAASEET AFPPVVEDEE MEASGVSGNE EEMVEEAEAT
VNNSSDTESI PSPRTEAAKD TGQNGPQPPA TLSTDGPPPE PPTPPPEDIP APTEPTPASE
ATGPPTPPPA PPSPSVPPPV VPKEEKEEEA AAVPPVEEGE EQKPPVAEEL AVDTGKAEEP
IKSECTEQAE EGPAKGKDAE ASEAMAEGAL KAEKKEGGSG RATTAKGSGA PQDSDSSATC
SADEVDEPEG GDKNRLLSPR PSLLTPTGDP RANASPQKPL DLKQLKQRAA AIPPIQVTKV
HEPPREDAAP TKPAPPAPPP PQHLQPESDA PQQPGSSPRG KSRSPAPPAD KEAEKPVFFP
AFAAEAQKLP GDPPCWTSGL PFPVPPREVI KASPHAPDPS AFSYAPPGHP LPLGLHDTAR
PVLPRPPTIS NPPPLISSAK HPSVLERQIG AISQGMSVQL HVPYSEHAKA PVGPVTMGLP
LPMDPKKLAP FSGVKQEQLS PRGQAGPPES LGVPTAQEAS VLRGTALGSV PGGSITKGVP
STRVPSDGAI TYRGSITHGT PADVLYKGTI TRIIGEDSPS RLDRGREDSL PKGHVIYEGK
KGHVLSYEGG MSVTQCSKED GRSSSGPPHE TAAPKRTYDM MEGRVGRAIS SASIEGLMGR
AIPPERHSPH HLKEQHHIRG SITQGIPRSY VEAQEDYLRR EAKLLKREGT PPPPPPPRDL
TEAYKTQALG PLKLKPAHEG LVATVKEAGR SIHEIPREEL RHTPELPLAP RPLKEGSITQ
GTPLKYDTGT STTGSKKHDV RSLIGSPGRT FPPVHPLDMM ADARALERAC YEESLKSRPG
TAGSSGGSIA RGAPVIVPEL GKPRQSPLTY EDHGAPFAGH LPRGSPVTTR EPTPRLQEGS
LSSSKASQDR KLTSTPREIA KSPHSTVPEH HPHPISPYEH LLRGVSGVDL YRSHIPLAFD
PNSIPRGIPL DAAAAYYLPR HLAPNPTYPH LYPPYLIRGY PDTAALENRQ TIINDYITSQ
QMHHNAATAM AQRADMLRGL SPRESSLALN YAAGPRGIID LSQVPHLPVL VPPTPGTPAT
AMDRLAYLPT APQPFSSRHS SSPLSPGGPT HLTKPTTTSS SERERDRDRE RDRDREREKS
ILTSSTTVEH APIWRPGTEQ SSGSSGSSGG GGGSSSRPAS HSHAHQHSPI SPRTQDALQQ
RPSVLHNTGM KGIITAVEPS TPTVLRSTST SSPVRPAATF PPATHCPLGG TLDGVYPTLM
EPVLLPKEAP RVARPERPRA DTGHAFLAKP PARPGLEPAS SPSKGSEPRP LAPPVSGHAT
IARTPAKNLA PHHASPDPPA PPASASDPHQ EKTQSKPFSI QELELRSLGY HGSSYSPEGV
EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP MKLGGEAAHL PHLRPLPESQ
PSSSPLLQTA PVVKGHQRVV TLAQHISEVI TQDYTRHHPQ QLSAPLPAPL YSFPGASCPV
LDLRRPPSDL YLPPPDHGAP ARGSPNSEGG KRSPEPSKTS VLGGGEDGIE PVSPPEGMTE
PGHSRSAVYP LLYRDGEQTE PSRMGSKSPG NTSQPPAFFS KLTESNSAMV KSKKQEINKK
LNTHNRNEPE YNIGQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGK
YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA KVSGRPSSRK
AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR PSSAGSTPFP YNPLIMRLQA
GVMASPPPPG LPAGSGPLAG PHHAWDEEPK PLLCSQYETL SDSE
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