ID A0A2K6RDP0_RHIRO Unreviewed; 754 AA.
AC A0A2K6RDP0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Tensin 4 {ECO:0000313|Ensembl:ENSRROP00000039152.1};
GN Name=TNS4 {ECO:0000313|Ensembl:ENSRROP00000039152.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000039152.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000039152.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR AlphaFoldDB; A0A2K6RDP0; -.
DR STRING; 61622.ENSRROP00000039152; -.
DR Ensembl; ENSRROT00000063629.1; ENSRROP00000039152.1; ENSRROG00000042906.1.
DR GeneTree; ENSGT00940000160142; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR CDD; cd01213; PTB_tensin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF6; TENSIN-4; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 449..595
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 121..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 80919 MW; C5EC0B012C14C4F2 CRC64;
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPMPCM
GPPDRLQQAP QAEAKATCFL PSPGEQALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP
QGTGGPRAEP AQSTMSVRKK EEPEALDIKY IEVTSARSRC HDGPQRCSSP SVTPPFGSPR
SGGLFLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPQPPNSPS ISIPCMGSKA
SSPHGLGSPL VASPRLEKRL GGLAPQRGSR ISMLSASPAS DVSYMFGSSQ SLLHSSNSGH
QSSSKSLESP ASSSSSLHSL GSVSPCTRPS DFQAPRNPTL TMGQPRAPHC PPLAKEHASS
CPPSITNSMV DIPIVLINGC PELGSSPPQR SPGHQSSVRP GAASPSNPCP ATRSHSQTLS
DASFTTCPEG PTRDMQPTMK FVMDTSKYWF KPNITREQAI ELLRKEEPGA FVIRDSSSYR
GSFGLALKVQ EVPPSAQNRP GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGEIPQPPGS
PGMGDQRSLS SELWGGLGKL YSCWAACFLS GSLSAFVCQH SIMALALPCK LTIPQRELGG
ADGASDSTDS PASCQRKSAG CHTLYLSSVS VETLTGALAV QKAVSTTFER DVLPTPTVVH
FKVTEQGITL TDVQRKVFFR RHYPLTTLRF CGMDPEQRKW QKYCKPSWIF GFVAKSQTEP
QENVCHLFAE YDTVQPASQV ISLVTALLQD AERM
//
