ID A0A2K6RJQ0_RHIRO Unreviewed; 485 AA.
AC A0A2K6RJQ0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Angiotensinogen {ECO:0000256|ARBA:ARBA00015105};
DE AltName: Full=Serpin A8 {ECO:0000256|ARBA:ARBA00033182};
GN Name=AGT {ECO:0000313|Ensembl:ENSRROP00000041259.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000041259.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000041259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the renin-angiotensin system (RAS), a
CC potent regulator of blood pressure, body fluid and electrolyte
CC homeostasis. {ECO:0000256|ARBA:ARBA00002747}.
CC -!- FUNCTION: Stimulates aldosterone release.
CC {ECO:0000256|ARBA:ARBA00029380}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; A0A2K6RJQ0; -.
DR STRING; 61622.ENSRROP00000041259; -.
DR Ensembl; ENSRROT00000065756.1; ENSRROP00000041259.1; ENSRROG00000043839.1.
DR GeneTree; ENSGT00890000139531; -.
DR OMA; GWKTGCS; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0031702; F:type 1 angiotensin receptor binding; IEA:Ensembl.
DR GO; GO:0031703; F:type 2 angiotensin receptor binding; IEA:Ensembl.
DR GO; GO:0038166; P:angiotensin-activated signaling pathway; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0002034; P:maintenance of blood vessel diameter homeostasis by renin-angiotensin; IEA:Ensembl.
DR GO; GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1901203; P:positive regulation of extracellular matrix assembly; IEA:Ensembl.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
DR GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0051247; P:positive regulation of protein metabolic process; IEA:Ensembl.
DR GO; GO:1903779; P:regulation of cardiac conduction; IEA:Ensembl.
DR GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR CDD; cd02054; serpinA8_AGT; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR000227; Angiotensinogen.
DR InterPro; IPR033834; Angiotensinogen_serpin_dom.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF13; ANGIOTENSINOGEN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR PRINTS; PR00654; ANGIOTENSNGN.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..485
FT /note="Angiotensinogen"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014331387"
FT DOMAIN 115..481
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 485 AA; 53076 MW; 48A578F6DF6B9744 CRC64;
TQKRAPQSEM APASVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG
KPKDPTFTPV PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM
HSELWGVVHG ATILSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDEN CTSRLDAHKV
LSALQAVQGL LVAQGRADGQ GQLLLSMVVG LFTAPDLHLK QPFVQGLALY APVVLPRSLD
FTDLEVAAEK IDRFMQAVTG WKISSPLTGA SADSTVVFNT YVHFQGKMKD FSLLAEPQEF
WVDNSTSVSV PMLSGVGTFQ HWSDSQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT
FQQNSLNWMK KLSPRAIRLT MPRLVLRGSY DLQDLLAQAE LPAILGTELN LQKLSTDNLR
VGKVLNSIFF ELEAAEREPT ESTRQLNRPE VLEVTLDHPF LFAVYDQSAT ALHFLGRVAN
PLSPA
//
