ID   A0A2K6RK25_RHIRO        Unreviewed;       653 AA.
AC   A0A2K6RK25;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=GLB1L3 {ECO:0000313|Ensembl:ENSRROP00000041365.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000041365.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000041365.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC         in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010360349.1; XM_010362047.1.
DR   AlphaFoldDB; A0A2K6RK25; -.
DR   STRING; 61622.ENSRROP00000041365; -.
DR   Ensembl; ENSRROT00000065863.1; ENSRROP00000041365.1; ENSRROG00000043881.1.
DR   GeneID; 104661427; -.
DR   KEGG; rro:104661427; -.
DR   CTD; 112937; -.
DR   GeneTree; ENSGT00950000182942; -.
DR   OrthoDB; 5489808at2759; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR048912; BetaGal1-like_ABD1.
DR   InterPro; IPR048913; BetaGal_gal-bd.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR   PANTHER; PTHR23421:SF59; BETA-GALACTOSIDASE-1-LIKE PROTEIN 3; 1.
DR   Pfam; PF21317; BetaGal_ABD_1; 1.
DR   Pfam; PF21467; BetaGal_gal-bd; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT   DOMAIN          80..390
FT                   /note="Glycoside hydrolase 35 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01301"
FT   DOMAIN          449..548
FT                   /note="Beta-galactosidase 1-like first all-beta"
FT                   /evidence="ECO:0000259|Pfam:PF21317"
FT   DOMAIN          572..631
FT                   /note="Beta-galactosidase galactose-binding"
FT                   /evidence="ECO:0000259|Pfam:PF21467"
FT   ACT_SITE        227
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT   ACT_SITE        301
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ   SEQUENCE   653 AA;  74697 MW;  38E1FEE5C69FC567 CRC64;
     MKSPPFLSPC LSWKRVVGVF FLPFVLSAFA PRFKQEENLM RGRAHPPQPR FNWSHLTPLE
     LKNRSVGLGT ASTGRGKPHF TLEGHKFLIF GGSIHYFRVP REYWRDRLLK LKACGFNTVT
     TYVPWNLHEP ERGKFDFSGN LDLEAFVLMA AEIGLWVILR PGPYICSEMD LGGLPSWLLR
     DPRLLLRTTN KGFTEAVEKY FDHLIPRVIP LQYRQGGPVI AVQVENEYGS FNKDKTYMPY
     LHKALLGRGI VELLLTSDGE KNVLSGHTKG VLAAINLQKV HTNTFSQLRE VQRDKPLLVM
     EYWVGWFDRW GDKHHVKDAK EVERAVSEFI KYEISFNVYM FHGGTNFGFM NGATYFGKHT
     GIVTSYDYDA VLTEAGDYTE KYFKLQKLFE SVSATPLPQV PKLTPKAVYP PMRPSLYLPL
     WDALSYLNEP VRSHQPVNME NLPINNGSGQ SYGLVLYEKS ICSGGRLCAH AHDMAQVFLD
     ETMIGILNEN NKDLHIPELR DCRYLRILVE NQGRVNFSWQ IQNEQKGITG SVSINNSSLE
     GFTIYSLEMK MSFFERLRSA TWKPVPESHR GPAFYRGTLK AGPSPKDTFL SLLNWNYGFV
     FINGRNLGRY WNIGPQKTLY LPGVWLHPED NEVILFEKML SGSDIKSTDK PML
//