ID A0A2K6RKP4_RHIRO Unreviewed; 223 AA.
AC A0A2K6RKP4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN Name=KCNMB3 {ECO:0000313|Ensembl:ENSRROP00000041604.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000041604.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000041604.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC {ECO:0000256|RuleBase:RU368097}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU368097}.
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DR AlphaFoldDB; A0A2K6RKP4; -.
DR Ensembl; ENSRROT00000066105.1; ENSRROP00000041604.1; ENSRROG00000043983.1.
DR GeneTree; ENSGT00950000183039; -.
DR OMA; KYSTAVR; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR10258:SF4; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-3; 1.
DR Pfam; PF03185; CaKB; 1.
DR PROSITE; PS00387; PPASE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW Ion channel {ECO:0000256|RuleBase:RU368097};
KW Ion transport {ECO:0000256|RuleBase:RU368097};
KW Membrane {ECO:0000256|RuleBase:RU368097};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transmembrane {ECO:0000256|RuleBase:RU368097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW Transport {ECO:0000256|RuleBase:RU368097}.
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 25656 MW; CB85928067A3D218 CRC64;
MDWKSFPASG KKRETDCSDG DPLDVHKRLS AQREELTCTA IHTDIMDDWL DCAFTCGVHC
RGQGKYPCLQ VLVNLTHSGQ KALLHYNEEA VQINPKCFYT PKCHQDRNDL LNIFLTLDIK
EFFDHKNGTP FSCFYSPDSQ SEDVILIKKY DQMAIFHCLF WSSLTLLGGA LIVGMVRLTQ
HLSLLCEKYS TVVRDEVGGK VPYIEQHQFK LWSMRRSKGR SRE
//
