ID   A0A2K6RMI2_RHIRO        Unreviewed;       189 AA.
AC   A0A2K6RMI2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Interleukin-18 {ECO:0000256|ARBA:ARBA00016740, ECO:0000256|PIRNR:PIRNR015162};
DE            Short=IL-18 {ECO:0000256|PIRNR:PIRNR015162};
GN   Name=IL18 {ECO:0000313|Ensembl:ENSRROP00000042237.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000042237.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000042237.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial
CC       barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK)
CC       cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a
CC       signaling ternary complex which activates NF-kappa-B, triggering
CC       synthesis of inflammatory mediators. Synergizes with IL12/interleukin-
CC       12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural
CC       killer (NK) cells. Involved in transduction of inflammation downstream
CC       of pyroptosis: its mature form is specifically released in the
CC       extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
CC       {ECO:0000256|PIRNR:PIRNR015162}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR015162}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC       ECO:0000256|PIRNR:PIRNR015162}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6RMI2; -.
DR   Ensembl; ENSRROT00000066742.1; ENSRROP00000042237.1; ENSRROG00000044274.1.
DR   GeneTree; ENSGT00390000001053; -.
DR   OMA; GKNFCLY; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR   GO; GO:0010557; P:positive regulation of macromolecule biosynthetic process; IEA:UniProt.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10078:SF35; INTERLEUKIN-18; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; Cytokine; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|PIRNR:PIRNR015162};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Secreted {ECO:0000256|PIRNR:PIRNR015162}.
SQ   SEQUENCE   189 AA;  21952 MW;  F2E5FDC2B91DE94B CRC64;
     MAAEPAEDNC INFVTMKFID NTLYFIENLE SDYFGKLESK LSIIRNLNDQ VLFIDQGNRP
     LFEDMTDSDC RDNAPRTIFI INMYKDSQPR GMAVAISVKC EKISTLSCEN RIISFKEMNP
     PDNIKDTKSD IIFFQRSVPG HDNKMQFESS SYEGYFLACE KERDLYKLIL KKKDELGDRS
     IMFTVQNED
//