ID A0A2K6RPM7_RHIRO Unreviewed; 322 AA.
AC A0A2K6RPM7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=G protein subunit alpha 12 {ECO:0000313|Ensembl:ENSRROP00000042987.1};
GN Name=GNA12 {ECO:0000313|Ensembl:ENSRROP00000042987.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000042987.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000042987.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR AlphaFoldDB; A0A2K6RPM7; -.
DR Ensembl; ENSRROT00000067498.1; ENSRROP00000042987.1; ENSRROG00000044582.1.
DR GeneTree; ENSGT00940000157636; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 322 AA; 37574 MW; 6732E9B7619E106B CRC64;
MKWRMCPRPC LARMLGSRGS GSIPDENGKR CCFEHVLIAH PGSRGSRVLV DARDKLGIPW
QYSENEKHGM FLMAFENKAG LPVEPATFQL YVPALSALWR DSGIREAFSR RSEFQLGESV
KYFLDNLDRI GQLNYFPSKQ DILLARKATK GIVEHDFVIK KIPFKMVDVG GQRSQRQKWF
QCFDGITSIL FMVSSSEYDQ VLMEDRRTNR LVESMNIFET IVNNKLFFNV SIILFLNKMD
LLVEKVKTVS IKKHFPDFRG DPHRLEDVQR YLVQCFDRKR RNRSKPLFHH FTTAIDTENV
RFVFHAVKDT ILQENLKDIM LQ
//
