ID A0A2K6RQ69_RHIRO Unreviewed; 1602 AA.
AC A0A2K6RQ69;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSRROP00000043179.1};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSRROP00000043179.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000043179.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000043179.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSRROT00000067690.1; ENSRROP00000043179.1; ENSRROG00000044453.1.
DR GeneTree; ENSGT00390000003017; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 64..134
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 200..270
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 368..438
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 506..576
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 644..714
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 785..830
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 924..1042
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1124..1240
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1347..1397
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1347..1397
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1602 AA; 183605 MW; E752194866159CA2 CRC64;
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY
KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF
NNAKAYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPT
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMS
NKRAVQGGRL SAITMALQYG SESEEDAALA AARYEEGESE AESITSFMDV SNPFYQLYDT
VRSCRNNQGQ LIAEPFFHLP SKKKYPDYYQ QIKMPISLQQ IRTKLKNQEY ETLDHLECDL
NLMFENAKRY NVPNSAIYKR VLKLQQVMQA KKKELARRDD IEDGDSMISS ATSDTGSAKR
KSKKNIRKQR MKILFNVVLE AREPGSGRRL CDLFMVKPSK KDYPDYYKII LEPMDLKIIE
HNIRNDKYAG EEGMIEDMKL MFRNARHYNE EGSQVYNDAH ILEKLLKEKR KELGPLPDDD
DMASPKLKLS RKSGISPKKS KYMTPMQQKL NEVYEAVKNY TDKRGRRLSA IFLRLPSRSE
LPDYYLTIKK PMDMEKIRSH MMANKYQDID SMVEDFVMMF NNACTYNEPE SLIYKDALVL
HKVLLETRRD LEGDEDSHVP NVTLLIQELI HNLFVSVMSH QDDEGRCYSD SLAEIPAVDP
NFPNKPPLTF DIIRKNVENN RYRRLDLFQE HMFEVLERAR RMNRTDSEIY EDAVELQQFF
IKIRDELCKN GEILLSPALS YTTKHLHNDV EKEKKEKLPK EIEEDKLKRE EEKREAEKSE
DSSGAAGLSG LHRTYSQDCS FKNSMYHVGD YVYVEPAEAN LQPHIVCIER LWEDSAGEKW
LYGCWFYRPN ETFHLATRKF LEKEVFKSDY YNKVPVSKIL GKCVVMFVKE YFKLCPENFR
DEDVFVCESR YSAKTKSFKK IKLWTMPISS VRFVPRDVPL PVVRVASVFA NADKGDDEKN
TDNSEDSRAE DSFNLEKEKE DVPVEMSNGE PGCHYFEQLH YNDMWLKVGD CVFIKSHGLV
RPRVGRIEKV WVRDGAAYFY GPIFIHPEET EHEPTKMFYK KEVFLSNLEE TCPMTCILGK
CAVLSFKDFL SCRPTEIPEN DILLCESRYN ESDKQMKKFK GLKRFSLSAK VVDDEIYYFR
KPIVPQKEPS PLLEKKIQLL EAKFAELEGG DDDIEEMGEE DSEVIEPPSL PQLQTPLASE
LDLMPYTPPQ STPKSAKGSA KKEGSKRKIN MSGYILFSSE MRAVIKAQHP DYSFGELSRL
VGTEWRNLET AKKAEYEGMM GGYPPGLPPL QGPVDGLVSM GSMQPLHPGG PPPHHLPPGV
PGLPGIPPPG VMNQGVAPMA GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ
QPTTPMFVAP PPKTQRLLHS EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR
LPSHWLKSKG AHTTMADALW RLRDLMLRDT LNIRQAYNLE NV
//
