ID A0A2K6RTM7_RHIRO Unreviewed; 1476 AA.
AC A0A2K6RTM7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSRROP00000044374.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSRROP00000044374.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000044374.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000044374.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR STRING; 61622.ENSRROP00000044374; -.
DR Ensembl; ENSRROT00000068890.1; ENSRROP00000044374.1; ENSRROG00000045139.1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140608; F:cysteine-type endopeptidase activator activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1904784; P:NLRP1 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 328..637
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1082..1367
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1383..1466
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1476 AA; 165852 MW; 65F53FEF78E93788 CRC64;
MAGRAWGRLA CYLELLKKEE LKEFQLLFAS KVHSSGSSGE TPTQLEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMGLR SLCTQAREGA DYSPSFPYSP SEPHLGSPSQ PTSTAVLRPW
NRDLPAECTQ GSERRVLRQL PDTSGHRWRE ISSSLLYQAL PSSPDFESPS QESPNAPTST
AVLASWGSPP QPSLAPREQE APGIQWPLDE MSGNYYTGIR EREREESEKG RTPWEAAVGT
PPQVHASVQP HRHPQEPSAR ESLCSTWSWK NDDLNQNFTQ LLLLQRPHPR SHKPLVKGSW
PHDVQEDRGR LIEIRDLFGP GLDTQEPRIV ILQGAAGTGK STLARQVRAA WGRGQLYGDR
FQHVFYFSCR ELAQCKVVSL AELIGKDWTA AQAPIRQILS RPERLLFILD GVDEPRWVLQ
EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
FSESSRREYF YKYFTDERQA VRALGLIQSN KELWALCLVP WVSWLACTCL MEQMKRKEEL
TLTSKTTTTL CLHYLSQALR AQPLGPQLGD VCSLAAEGIW QKKTLFSQDD LRKHELDGAI
VSTLLKMGIL QGHPIPLSYS FIHLCFQEFF AAMSYALEDK KGRGKHSDCI IDLEKLLAAY
GTHGLFGAPT TRFLLGLLSD EGKRAMENIF NCRLSQGRNL KQWVPSLQPL LQPHSLEFLH
CLYETQNKTF LTQMMADFQE MGMCVETDME LLVCTFCIKF CHHVKKLQLI EGRQHRPAWS
PTGTVLFRWV PVTDAYWEIL FSILKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE
TLRLASCGLT AEDCKDLASG LRVNQNLTVL DLSFNVLTDA GARYLCQRLS WPFCTLQRLQ
LVSCGLTSGC CQDLASVLST SPLLMELDLQ QNNLGNTGVQ LLCEGLRHPA CQLTRLGLDQ
TTLSDEMRQE LRALEQKKPQ LLIFSTWKPT EMIPNEGLGT GETSNSTSSL KRQRLRSETE
SSHVAQADLK PLDWSNLPAK ASQSAGITEG SSPEVEQVEP LCLPSPASLG DQDTPLGTDD
DFWGPTGPVA TEVVDKERSL YRVHFPVAGS YRWPNTGLCF VVREAVTTEI EFCVWDQFLG
EINPQHSWMV AGPLLDIKAE PGAVEAVHLP HFVALQGGHV DTSLFQVAHF KEEGMLLEKP
ARAELHHIVL ENPSFSPLGV LLKVIHSTLR FFPVNSLVLL YHRLHPEEVT FHLYLIPSDC
SIRKAIDDEE TKFQFVRIHK PPPLTPLYMG CRYTVSGSGS GMLEILPKEL ELCYRSPGEA
QLFSEFYVGH LGSGIRLQMK DKKDETLVWE ALVKPGDLTS ATTLVPPAPI ALPSPLDAPG
LLHFVDQYRE QLIARVTSVE AVLDKLHGQV LSQEQYERVL AEDTRPSQMR KLFSSSQSWD
RRCKDRFYQA LKETHPHLIM ELWEKGSKKG LLPLHS
//
