ID A0A2K6RTM9_RHIRO Unreviewed; 1432 AA.
AC A0A2K6RTM9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSRROP00000044376.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSRROP00000044376.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000044376.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000044376.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSRROT00000068892.1; ENSRROP00000044376.1; ENSRROG00000045139.1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 328..637
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1082..1323
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1339..1422
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1432 AA; 160946 MW; 54CD02F5EE00FE3D CRC64;
MAGRAWGRLA CYLELLKKEE LKEFQLLFAS KVHSSGSSGE TPTQLEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMGLR SLCTQAREGA DYSPSFPYSP SEPHLGSPSQ PTSTAVLRPW
NRDLPAECTQ GSERRVLRQL PDTSGHRWRE ISSSLLYQAL PSSPDFESPS QESPNAPTST
AVLASWGSPP QPSLAPREQE APGIQWPLDE MSGNYYTGIR EREREESEKG RTPWEAAVGT
PPQVHASVQP HRHPQEPSAR ESLCSTWSWK NDDLNQNFTQ LLLLQRPHPR SHKPLVKGSW
PHDVQEDRGR LIEIRDLFGP GLDTQEPRIV ILQGAAGTGK STLARQVRAA WGRGQLYGDR
FQHVFYFSCR ELAQCKVVSL AELIGKDWTA AQAPIRQILS RPERLLFILD GVDEPRWVLQ
EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
FSESSRREYF YKYFTDERQA VRALGLIQSN KELWALCLVP WVSWLACTCL MEQMKRKEEL
TLTSKTTTTL CLHYLSQALR AQPLGPQLGD VCSLAAEGIW QKKTLFSQDD LRKHELDGAI
VSTLLKMGIL QGHPIPLSYS FIHLCFQEFF AAMSYALEDK KGRGKHSDCI IDLEKLLAAY
GTHGLFGAPT TRFLLGLLSD EGKRAMENIF NCRLSQGRNL KQWVPSLQPL LQPHSLEFLH
CLYETQNKTF LTQMMADFQE MGMCVETDME LLVCTFCIKF CHHVKKLQLI EGRQHRPAWS
PTGTVLFRWV PVTDAYWEIL FSILKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE
TLRLASCGLT AEDCKDLASG LRVNQNLTVL DLSFNVLTDA GARYLCQRLS WPFCTLQRLQ
LVSCGLTSGC CQDLASVLST SPLLMELDLQ QNNLGNTGVQ LLCEGLRHPA CQLTRLGLDQ
TTLSDEMRQE LRALEQKKPQ LLIFSTWKPT EMIPNEGLGT GETSNSTSSL KRQRLRSETE
SSHVAQADLK PLDWSNLPAK ASQSAGITEG SSPEVEQVEP LCLPSPASLG DQDTPLGTDD
DFWGPTGPVA TEVVDKERSL YRVHFPVAGS YRWPNTGLCF VVREAVTTEI EFCVWDQFLG
EINPQHSWMV AGPLLDIKAE PGAVEAVHLP HFVALQGGHV DTSLFQVAHF KEEGMLLEKP
ARAELHHIVL ENPSFSPLGV LLKVIHSTLR FFPVNSLVLL YHRLHPEEVT FHLYLIPSDC
SIRKELELCY RSPGEAQLFS EFYVGHLGSG IRLQMKDKKD ETLVWEALVK PGDLTSATTL
VPPAPIALPS PLDAPGLLHF VDQYREQLIA RVTSVEAVLD KLHGQVLSQE QYERVLAEDT
RPSQMRKLFS SSQSWDRRCK DRFYQALKET HPHLIMELWE KGSKKGLLPL HS
//
