ID   A0A2K6RTQ9_RHIRO        Unreviewed;       215 AA.
AC   A0A2K6RTQ9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Neuroblastoma suppressor of tumorigenicity 1 {ECO:0000256|ARBA:ARBA00015324};
GN   Name=NBL1 {ECO:0000313|Ensembl:ENSRROP00000044409.1};
OS   Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000044409.1, ECO:0000313|Proteomes:UP000233200};
RN   [1] {ECO:0000313|Ensembl:ENSRROP00000044409.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
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DR   AlphaFoldDB; A0A2K6RTQ9; -.
DR   Ensembl; ENSRROT00000068925.1; ENSRROP00000044409.1; ENSRROG00000045168.1.
DR   GeneTree; ENSGT00940000154209; -.
DR   Proteomes; UP000233200; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF5; NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF018557; DAN_sub; 1.
DR   SMART; SM00041; CT; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          71..158
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|SMART:SM00041"
FT   REGION          166..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..202
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  23251 MW;  B8809928A8154E9F CRC64;
     MCSPALQQLI SMDLFWRLFL VCGQEGLWAL EATGMMLRVL MGAVLPAMLL AAPPPINKLA
     LFPDKSAWCE AKNITQIVGH SGCEAKSIQN RACLGQCFSY SVPNTFPQST ESLVHCDSCM
     PAQSMWEIVT LECPGHEEVP RVDKLVEKIL HCSCQACGKE PSHEGLSVYV QGEDGPGSQP
     GTHPHPHPHP HPGGQTPEPE DPPGAPHTEE EGAED
//