ID A0A2K6RVK5_RHIRO Unreviewed; 2565 AA.
AC A0A2K6RVK5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myosin XVIIIB {ECO:0000313|Ensembl:ENSRROP00000045059.1};
GN Name=MYO18B {ECO:0000313|Ensembl:ENSRROP00000045059.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000045059.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000045059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_010373893.1; XM_010375591.1.
DR STRING; 61622.ENSRROP00000045059; -.
DR Ensembl; ENSRROT00000069579.1; ENSRROP00000045059.1; ENSRROG00000045452.1.
DR Ensembl; ENSRROT00000069582.1; ENSRROP00000045062.1; ENSRROG00000045452.1.
DR GeneTree; ENSGT00940000158067; -.
DR OMA; CISSEGP; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0016461; C:unconventional myosin complex; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR CDD; cd01386; MYSc_Myo18; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF8; UNCONVENTIONAL MYOSIN-XVIIIB; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 571..1333
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 12..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2139..2191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2357..2379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2448..2556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1401..1668
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1700..1774
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1889..1958
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2021..2083
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 41..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2139..2156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2170..2185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2224..2240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2357..2372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2503..2519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2537..2556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 660..667
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2565 AA; 285447 MW; 79DDCE2F9A235A73 CRC64;
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRETEKEAK EARQRKQLAL
AAPERETPEI SISEPNSKSS SGTRSGSQQI SQDNQSSSPG SSDILSKESE GTGSPNPERM
TSINGEKAQE LGSTATPAKK TLPFKRGMRR GDVLLMVAKL DLDSAKPERT HPHDTSPCKT
PPPVTDTGKE RKGETSRAPC GPQASTEILA PKAEKTRTGG LGDAGQGTVA LKKGEKGQSI
VGKGGGTPKT KELKEAEPQG KDRQGTRPQA QGPSEGVRPG KAEKEGGEPT SPVEKENVSK
NVGSEGKHIG PHIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE PQTQTEKKSQ
MQGELGDDLR MGEKAGELRS MTGKAGESWD KKEKIGQPQG KSGKAGEARS QTEKGCEAPK
EVSTMVESPV AAGKGGWSGR SGQEAEGPCS REDVGSGALE TELEGPSQPA LEKDAERPRI
QKENQDGPAP QEAGKGGQSR NSEQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP
AGRVRLCIDA DKSITEVDEE HVHRANPPEL DQAEDLASLI SVNESSVLNT LLQRYRAQRP
HTCTGPDLIV LQPRGPSVPS AGKVPKGRWD GLPAHIGSMA QRAYWALLNQ RRDQSIVALG
RSGAGKTACC EQVLEHLVGM AGSMDGKVSV EKIRATFTVL WAFGSVSMAH SCSATRFSMV
MSLDFNATGR ITAAQLQTML LEKSRVARQP EGESNFQVFS QMLAGLDLDL RMELNLHQMA
DSSSFGMGMW SKPEDKQKAA AAFAQLQGAM ETLGISESEQ RAIWRVLAAI YHLGAAGACK
VGRKQFMRFE WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSQRD LEDEETSSGL
KMTGVECVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ NPRHQGKDRA
ATFEELCHNY AHERLQLLFY QRTFVSTLQR YREEGVPVQF DLPDLSPGTT VAAVDHNPSQ
VRLPAGGGAQ DAKGLFWVLD EEVRVEGSSD SVVLERLCAA FEKKGAGTEG SSALRTCEQP
LQCEIFHQLG WDPVRYDLTG WLHRAKPNLS ALDAPQVLQQ SKREELRSLF QSRAKLPPVC
QAVAGLEGTS QQALQRNRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH
CLVLNPVVES RSEQESPTPP QPGRDKPGAD APLALDIPAL RVQLAGFHIL EALRLHRTGY
ADNMGLTHFR RQFQVLDPPL LKKLMSTSEG IDERKAVEEL LETLDLEKKA VALGHSQVFL
KAGVISRLER QREKLVSQSI VLFQAACKGF LSRQEFKKLK IRRLAAQCIQ KNVAMFLAVK
DWPWWQLLGS LRPLLSATIG NEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA
DLTTELADER FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ
KIQLNDLERN PAGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR KELEQKLGEL
QSAYDGAKKM AHQLKRKCHH LTCDLEDTRV LLENQQSRNH ELEKKQKKFD LQLAQALGES
VFEKGLREKV TQENTSVRWE LGQLQQQLKQ KEQEALQLKQ EVEMLQDHKW ELLGSPSLGE
NCIAGLKERL WKLESSALEQ QKVQSQQENT IKQLEQLRQR FELEIERMKQ IHQKDREDQE
EELEDVRQSC QKRLRQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL
RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA LKTQKVLTAD
LESMHSELEN MTRNKSLVDE QLYRLQFEKT DLLKRIDEDQ DDLNELMQKH KDLIAQSAAD
IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM RIEYLEQSTV DRAIVSRQEA VICDLENKTE
FQKVQIKRFE VLVIRLRDSL IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ
REAEASRRCM ELEKYVEELG AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA
VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSMATDTM RTPSRQSATS SRILSPRINE
EAGDAERTQS ALSRAWSTDV RSKTSGDKPV SPHFVRRQKY CHFGDGEGLA VQRKSAERLE
AASSPLASRS TNTSPLSREK LPSPSAALSE FVEGLRRKRA QRGQGSTLGL EDWPTLPIYL
TTGASTLRRG RAGSDKGNLS LRVGAKSPLE IEGAAGGLLR STSLKCISSD GVGGTTLLPE
KAKTRFSSCE SLLESRPSMG RKLSSPTTPR DMLLSPTLRP RRRCLESSVD DAGCPDLGKE
PLVFQNRQFA HLMEEPLGSD PFSWKLPSLD YERKTKVDFD DFLPAIRKPQ MPTSLAGAAK
DGQDGSQRSS VHFETEEADR SFLSGIKTIL KKSPEPKEDP AHLSDSSSSS SSIVSFKSAD
SIKSRPGIQR LAGDGGEGTS PEHREPGAGR KDDDVTSIMK KYLQK
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