ID A0A2K6RWQ8_RHIRO Unreviewed; 910 AA.
AC A0A2K6RWQ8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSRROP00000045462.1};
GN Name=PIDD1 {ECO:0000313|Ensembl:ENSRROP00000045462.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000045462.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000045462.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010386676.1; XM_010388374.1.
DR AlphaFoldDB; A0A2K6RWQ8; -.
DR STRING; 61622.ENSRROP00000045462; -.
DR Ensembl; ENSRROT00000069983.1; ENSRROP00000045462.1; ENSRROG00000045626.1.
DR GeneID; 104681912; -.
DR KEGG; rro:104681912; -.
DR CTD; 55367; -.
DR GeneTree; ENSGT00940000161780; -.
DR OMA; HRDNLGA; -.
DR OrthoDB; 894110at2759; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR CDD; cd08779; Death_PIDD; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 322..454
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 455..596
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 788..873
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 884..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 444
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 446
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 586
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 588
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 445..446
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 587..588
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 910 AA; 99763 MW; 7A11B8C0F3B34BBF CRC64;
MAAAVEGPEL EAAAAAGDAS EDADAGSRAL PFLGGNWLSL DLYPGGCQRL LHLCVQQPLQ
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTTLPSS
LSGLAHLAHL DLSFNSLETL PACVLRMRGL GALLLSHNCL SELPEALGAL PALTFLAVTH
NCLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR
SLRLLVLHSN LLASVPASLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP
DVPSSPVAAL IPEMPRLFLT SDLDSFPVTP RGCSVTLACG VRLQFPAGAT ATPITIRYRL
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPRARRCRE VVVRTRNDNS
WGDLETYLEE EAPQRLWAHC QAPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS
GVTGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV
EMFEGEEFFA AFERGINVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ
VSFYRGAVPV QVPEEAEAAR QRKGADALWM ATLPIKLPRL RSSEEPRWGA GLSLAPLNLG
DAETGFLTQS NLLSVAGRLG PDWPTVALHL GVSYRELQRI RHEFRDDLDG QIRHMLFSWA
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR TVLELGCRKY QDRIQRTGLA PKDPALPGSS
APQPPEPAQA
//
