ID A0A2K6RWZ5_RHIRO Unreviewed; 842 AA.
AC A0A2K6RWZ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN Name=MCM8 {ECO:0000313|Ensembl:ENSRROP00000045549.1};
OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000045549.1, ECO:0000313|Proteomes:UP000233200};
RN [1] {ECO:0000313|Ensembl:ENSRROP00000045549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR AlphaFoldDB; A0A2K6RWZ5; -.
DR Ensembl; ENSRROT00000070070.1; ENSRROP00000045549.1; ENSRROG00000045665.1.
DR GeneTree; ENSGT01090000260080; -.
DR OMA; THTVDWQ; -.
DR Proteomes; UP000233200; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006259; P:DNA metabolic process; IEA:UniProt.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000233200}.
FT DOMAIN 417..611
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 15..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 94054 MW; C75160FA64F64C20 CRC64;
MNGEYRGRGF GRGRFQSWKR GRGGGNFSGK WRGRGHRPDL SKTTGKHTSE QTPQSLLSTK
TPQSMQSTLD RLIPYKGWKL YFSEVYSDSS PLIEKIQAFE KFFTRHIYLY DKDEIERKGS
ILVDFKELIE DDEVTNLIPD TANELRDAPE KTLACMGLAI HQVLTKDLER HAAELQAQEG
LSSDGETMVN VPHIHARVYN YEPLTQLKNV RANYYGKYIA LRGTVVRVSN IKPLCTKMAF
LCAACGEVQS FPLPDGKYSL PTKCPVPACR GRSFTALRSS PLTVTMDWQS IKIQELMSDD
QREAGRIPRT IECELVHDLV DSCVPGDTVT VTGIVKVSNA EEGSRNKNDK CMFLLYIEAN
SISNSKGQKT KSSEDGCKHG MLMEFSLKDL YAIQEIQAEE NLFKLIVKYV CCHLKFYYID
LVKAGLALAL FGGSQKYADD KNRIPIRGDP HILVVGDPGL GKSQMLQAAC NVAPRGVYVC
GNTTTTSGLT VTLSKDSSSG DFALEAGALV LGDQGICGID EFDKMGNQHQ ALLEAMEQQS
ISLAKAGVVC SLPARTSIIA AANPVGGHYN KAKTVSENLK MGSALLSRFD LVFILLDTPN
EHHDHLLSEH VIAIRAGKQR TISSVTVARM NSQDSNTSVL EVVSEKPLSE RLKVVPGETI
DPIPHQLLRK YIGYARQYVY PRLSKEAAQV LQDFYLELRK QSQRLNSSPI TTRQLESLIR
LTEARARLEL REEATKEDAE DIVEIMKYSM LGTYSDEFGN LDFERSQHGS GMSNRSTAKR
FISALNNIAE RTYNNIFQFH QLRQIAKELN IQVADFENFI GSLNDQGYLL KKGPKVYQLQ
TM
//
