ID A0A2K6S0H7_SAIBB Unreviewed; 1807 AA.
AC A0A2K6S0H7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSSBOP00000000885.1};
GN Name=TSC2 {ECO:0000313|Ensembl:ENSSBOP00000000885.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000000885.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000000885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_003928465.1; XM_003928416.2.
DR STRING; 39432.ENSSBOP00000000885; -.
DR Ensembl; ENSSBOT00000004414.1; ENSSBOP00000000885.1; ENSSBOG00000003087.1.
DR GeneID; 101031475; -.
DR CTD; 7249; -.
DR GeneTree; ENSGT00950000183139; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0043276; P:anoikis; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 1531..1758
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1769..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1807 AA; 200701 MW; C3DE49FA8F2FFB53 CRC64;
MAKPASKDSG LKEKFKNLLG LGTPRPNPRS AEGKQTEFII TAEVLRELSV ECGLNNRIRM
IGQICEVAKT KKFEEHAVEA LWKAVADMLQ PERPLEARHA VLALLKAIVQ GQGERLGILR
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL ADFVLQWMDV GLSSEFLLVL
VNLVKFNSCY LDEYIARMVQ MICLLCVRTA SSVDIEVSLQ VLDAVVCYNC LPAESLPVFI
VTLCRTINVK ELCEPCWKLM RNLLGTHLGH SAIYNMCHLM EDRAYMEDAP LLRGAVFFVG
MALWGAHRLY SLRNSPTSVL PSFYQAMACA NEVVSYEIVL SITRLIKKYR KELQAVTWDI
LLNIIERLLQ QLQTLDSLEL RTIVHDLLTT VEELCDQNEF HGSQERYFEL VERCADQRPE
SSLLNLISYR AQSIHPAKDG WIQNLQVLME RFFRSESRGA VRIKVLDVLS FVLLINRQFY
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMTRSLS
PPPELEERDV AAYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYEML VSHIQLHYKH
NYTLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCVCDYME PERGSEKKAS
GSLSPPTGPS GPTPAGPAVR LGSLPYSLLF RVLLQCLKQE TDWKVLKLVL GRLPESLRYK
VLIFTSPCSV DQLCSALCSM LSGPKTVERL RGAPEGFSRT DLHLAVVPVL TALISYHNYL
DKTKQREMVY CLEQGLVHRC ASQCVVALSI CSVEMPDIII KALPVLVVKL THISATASMA
VPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
RLPFRKDFVP FITKGLRSNV LLSFDDTPEK DSFRARSTSL NERPKSLRIA RPPKQGLNNS
PPVKEFKESS AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSVAQ ADDSLKNLHL
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
LGLDSGELQA GPELSSSPGV HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
TLDVPASQFP GSATSPGPQT APATKPEKAS ASTRVPVQEK TNLAAYVPLL TQGWAEILVR
RPTGNTSWLM SLENPLSPFS SDINSMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAST
AKPPPLPRSN TVASFSSLYQ SGCQGQLHRS VSWADSAVVM EEGSPGEVPA PVEPPELEDF
EAALGTDRRA DAYSRSSSTS SQEEKSFHAE ELVARGIPIE RAVSSEGGRP SVDLSFQPSQ
PLSKSSSSPE LQTLQDILGD PGDKAEVGRL SPEVKARSQS GILDGDSAAW SAPGEDSRGQ
PEGPLPSSSP RSPSGLRPRG YTISDSAPSR RGKRVERDAF KSRAAASNAE KVPGINPSFV
FLQLYHSPFF GDESNKPILL PNESQSFERS VQLLDQIPSY DTHKIAVLYV GEGQSNSELA
ILSNEHGSYR YTEFLTGLGR LIELKDCQPD KVYLGGLDVC GEDGQFTYCW HDDIMQAVFH
IATLMPTKDV DKHRCDKKRH LGNDFVSIVY NDSGEDFKLG TIKGQFNFVH VIITPLDYEC
NLVSLQCRKD MEGLVDTSVA KIVSDRNLSF VARQMALHAN MASQVHHSRS NPTDIYPSKW
IARLRHIKRL RQRICEEAPY SNPSLPLVHP PAHAKAPAQT PAEPTPGYEM GQRKRLISSV
EDFTEFV
//
