ID A0A2K6S161_SAIBB Unreviewed; 359 AA.
AC A0A2K6S161;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=VPS37C subunit of ESCRT-I {ECO:0000313|Ensembl:ENSSBOP00000001121.1};
GN Name=VPS37C {ECO:0000313|Ensembl:ENSSBOP00000001121.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000001121.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000001121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR RefSeq; XP_010333620.1; XM_010335318.1.
DR RefSeq; XP_010333623.1; XM_010335321.1.
DR AlphaFoldDB; A0A2K6S161; -.
DR STRING; 39432.ENSSBOP00000001121; -.
DR Ensembl; ENSSBOT00000005819.1; ENSSBOP00000001121.1; ENSSBOG00000005239.1.
DR KEGG; sbq:101046549; -.
DR GeneTree; ENSGT00950000183012; -.
DR OMA; PMYRAGY; -.
DR OrthoDB; 5317586at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0036258; P:multivesicular body assembly; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37C; 1.
DR Pfam; PF07200; Mod_r; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 78..167
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 159..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..94
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 169..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 38929 MW; F37DFB9AC0238CAF CRC64;
METLKDKTLQ ELEELQNDSE AIDRLALESP EVQDLQLERE MALATNRSLA EQNLEFQGPL
EISRSNLSDK YQELRKLVER CQEQKAKLEK FSSALQPGTL LDLLQVEGMK IEEESEAMAE
KFLEGEVPLE TFLESFSSMR MLSHLRRVRV EKLQEVVRKP RASQELAGDA PPPRPPPPPP
PPRPVPQATP PVVEEQPQPP PSAMPPYPLP YSPSPSLPVG PTACGALPPA PFPVVSQPSF
YSGPLGPTYP AAQPGPRAAA GYSWSPQRST PPRPGYPGTP TGASGPGYPV AGVRVPSPGY
PQQSPYPEAG GKPPYPIQPQ LPGFPGQPQP SMPPQPPYPP GPAPPYGFPQ PQGPAWPGY
//
