ID A0A2K6S1S4_SAIBB Unreviewed; 1123 AA.
AC A0A2K6S1S4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000313|Ensembl:ENSSBOP00000001332.1};
GN Name=ADGRA3 {ECO:0000313|Ensembl:ENSSBOP00000001332.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000001332.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000001332.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR RefSeq; XP_010336465.1; XM_010338163.1.
DR AlphaFoldDB; A0A2K6S1S4; -.
DR Ensembl; ENSSBOT00000007282.1; ENSSBOP00000001332.1; ENSSBOG00000006417.1.
DR KEGG; sbq:101045043; -.
DR GeneTree; ENSGT00940000157235; -.
DR OMA; XFYLIGG; -.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 565..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..221
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 562..747
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 876..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 125245 MW; AB46364BEA5BA5F3 CRC64;
MHRWVKERNI TVRDTRCVYP KSLQAQPVTG VKQELLTCGP PLELPSFYMT PSHRQVVFEG
DSLPFQCMAS YIDQDMQVLW YQDGRIVETD ESQGIFVEKN MIHNCSLIAS ALTISNIQAG
STGNWGCHVQ TKRGNNTRTV DIVVLESSAQ YCPPERVVNN KGDFRWPRTL AGITAYLQCT
RNSHGSGIYP GSPQDERKAW RRCDRGGFWA DDDYSRCQYA NDVTRVLYMF NQMPLNLTNA
VATARQLLAY TVEAANFSDK MDVIFVAEMI EKFGRFTKEE KSKELGDVMV DIASNIMLAD
ERVLWLAQRE AKACSRIVQC LQRVATYRLA SGAHVYSTYS PNIALEAYVI KPTGFSGMTC
TVFQKVAASD RTGLSDYGRR DPDGNLDKQL SFKCNVSNTF SSLALKNTIV EASIQLPPSL
FSPKQKRELR PTDDSLYKLQ LLAFRNGKLF PATGNSTNLA DDGKRRTVVT PVILTKIDGM
NVDTHHIPVN VTLRRIAHGA DAVAARWDFD LLNGQGGWKS DGCHILYSDE NITTIQCYSL
SNYAVLMDLT GSELYTQAAS LLHPMVYTTA IILLLCLLAV IVSYIYHHSL IRISLKSWHM
LVNLCFHIFL TCVVFVGGIT QTRNASVCQA VGIILHYSTL ATVLWIGVTA RNIYKQVTKK
AKRCQDPDEP PPPPRPMLRF YLIGGGIPII VCGITAAANI RNYGSRPNAP YCWMAWEPSL
GAFYGPASFI TFVNCMYFLS IFIQLKRHPE RKYELKEPTE EQQRLAANEN GEINHQDSMS
LSLISTSVLE NEHTFHSQLL GASLTLLLYV ALWMFGALAV SLYYPLDLVF SFVFGATCLS
FSAFFMVHHC VNREDVRLAW IMTCCPGRSS YSVQVNVQPP NSSGTNGEAP KCPNSSAESS
CTNKSASSFK NSSQGCKLTN LQAAAAQCHA NSLPLNTPQL DNSLTEHSMD NDIKMHVAPL
EVQFRTNVHS SRHHKNRSKG HRASRLTVLR EYAYDVPTSV EGSVQNGLPK SRLGTNEGHS
RSRRAYLAYR ERQYNPPQQD SSDACSTLPK SSRNFEKPVS TSSKKDTLRK PAVVELENQQ
KSYGLNLAIQ NGPIKSNGQE GPLLGTDSTG NVRTGLWKHE TTV
//
