ID A0A2K6S1W9_SAIBB Unreviewed; 1246 AA.
AC A0A2K6S1W9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000313|Ensembl:ENSSBOP00000001368.1};
GN Name=ADGRA3 {ECO:0000313|Ensembl:ENSSBOP00000001368.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000001368.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000001368.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR AlphaFoldDB; A0A2K6S1W9; -.
DR STRING; 39432.ENSSBOP00000001368; -.
DR Ensembl; ENSSBOT00000007380.1; ENSSBOP00000001368.1; ENSSBOG00000006417.1.
DR GeneTree; ENSGT00940000157235; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 688..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 951..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..266
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 249..344
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 685..870
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 999..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 138616 MW; F1F55E3A7E552E49 CRC64;
GAGRAAGAAE GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL
DLRNNLISSI DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLEF QTEYLLCDCN
ILWMHRWVKE RNITVRDTRC VYPKSLQAQP VTGVKQELLT CGPPLELPSF YMTPSHRQVV
FEGDSLPFQC MASYIDQDMQ VLWYQDGRIV ETDESQGIFV EKNMIHNCSL IASALTISNI
QAGSTGNWGC HVQTKRGNNT RTVDIVVLES SAQYCPPERV VNNKGDFRWP RTLAGITAYL
QCTRNSHGSG IYPGSPQDER KAWRRCDRGG FWADDDYSRC QYANDVTRVL YMFNQMPLNL
TNAVATARQL LAYTVEAANF SDKMDVIFVA EMIEKFGRFT KEEKSKELGD VMVDIASNIM
LADERVLWLA QREAKACSRI VQCLQRVATY RLASGAHVYS TYSPNIALEA YVIKPTGFSG
MTCTVFQKVA ASDRTGLSDY GRRDPDGNLD KQLSFKCNVS NTFSSLALKN TIVEASIQLP
PSLFSPKQKR ELRPTDDSLY KLQLLAFRNG KLFPATGNST NLADDGKRRT VVTPVILTKI
DGMNVDTHHI PVNVTLRRIA HGADAVAARW DFDLLNGQGG WKSDGCHILY SDENITTIQC
YSLSNYAVLM DLTGSELYTQ AASLLHPMVY TTAIILLLCL LAVIVSYIYH HSLIRISLKS
WHMLVNLCFH IFLTCVVFVG GITQTRNASV CQAVGIILHY STLATVLWIG VTARNIYKQV
TKKAKRCQDP DEPPPPPRPM LRFYLIGGGI PIIVCGITAA ANIRNYGSRP NAPYCWMAWE
PSLGAFYGPA SFITFVNCMY FLSIFIQLKR HPERKYELKE PTEEQQRLAA NENGEINHQD
SMSLSLISTS VLENEHTFHS QLLGASLTLL LYVALWMFGA LAVSLYYPLD LVFSFVFGAT
CLSFSAFFMV HHCVNREDVR LAWIMTCCPG RSSYSVQVNV QPPNSSGTNG EAPKCPNSSA
ESSCTNKSAS SFKNSSQGCK LTNLQAAAAQ CHANSLPLNT PQLDNSLTEH SMDNDIKMHV
APLEVQFRTN VHSSRHHKNR SKGHRASRLT VLREYAYDVP TSVEGSVQNG LPKSRLGTNE
GHSRSRRAYL AYRERQYNPP QQDSSDACST LPKSSRNFEK PVSTSSKKDT LRKPAVVELE
NQQKSYGLNL AIQNGPIKSN GQEGPLLGTD STGNVRTGLW KHETTV
//
