ID A0A2K6S6S2_SAIBB Unreviewed; 574 AA.
AC A0A2K6S6S2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lamin A/C {ECO:0000313|Ensembl:ENSSBOP00000003079.1};
GN Name=LMNA {ECO:0000313|Ensembl:ENSSBOP00000003079.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000003079.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000003079.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A2K6S6S2; -.
DR Ensembl; ENSSBOT00000016901.1; ENSSBOP00000003079.1; ENSSBOG00000014857.1.
DR GeneTree; ENSGT00940000157244; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF5; PRELAMIN-A_C; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 1..275
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 316..433
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 272..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..257
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 279..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 64045 MW; 6EF6B19669663D74 CRC64;
MGNSEGCNTK KEGDLLAAQA RLKDLEALLN SKEAALSTAL SEKRTLEGEL HDLRGQVAKL
EAALGEAKKQ LQDEMLRRVD AENRLQTLKE ELDFQKNIYS EELRETKRRH ETRLVEIDNG
KQREFESRLA DALQELRAQH EDQVEQYKKE LEKTYSAKLD NARQSAERNS NLVGAAHEEL
QQSRIRIDSL SAQLSQLQKQ LAAKEAKLRD LEDSLARERD TSRRLLAEKE REMAEMRARM
QQQLDEYQEL LDIKLALDME IHAYRKLLEG EEERLRLSPS PTSQRSRGRA SSHSSQTQGT
GSITKKRKLE STESRSSFSQ HARTSGRVAV EEVDEDGKFV RLRNKSNEDQ SMGNWQIKRQ
NGDDPLLTYR FPPKFTLKAG QVVTIWAAGA GATHSPPTDL VWKAQNTWGC GNSLRTALIN
STGEEVAMRK LVRSVTVVED DEDEDGDDLL HHHHGSHCSS SGDPAEYNLR SRTVLCGTCG
QPADKASASS SGAQVGGSIS SGSSASSVTV TRSYRSVGGS GGGSFGDHLV TRSYLLGNSR
PRTQSPQNCT IIQEMGMRWE VEEGRRKVSL SCLP
//
