ID A0A2K6S6S7_SAIBB Unreviewed; 491 AA.
AC A0A2K6S6S7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lamin A/C {ECO:0000313|Ensembl:ENSSBOP00000003084.1};
GN Name=LMNA {ECO:0000313|Ensembl:ENSSBOP00000003084.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000003084.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000003084.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A2K6S6S7; -.
DR Ensembl; ENSSBOT00000016907.1; ENSSBOP00000003084.1; ENSSBOG00000014857.1.
DR GeneTree; ENSGT00940000157244; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF5; PRELAMIN-A_C; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 1..306
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 347..464
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 303..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 310..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55697 MW; 5C3AD8C34D9A164E CRC64;
MPPLLCLGNL EDARERAGAL LARHPAWGRT QAKPGSPLNT KKEGDLLAAQ ARLKDLEALL
NSKEAALSTA LSEKRTLEGE LHDLRGQVAK LEAALGEAKK QLQDEMLRRV DAENRLQTLK
EELDFQKNIY SEELRETKRR HETRLVEIDN GKQREFESRL ADALQELRAQ HEDQVEQYKK
ELEKTYSAKL DNARQSAERN SNLVGAAHEE LQQSRIRIDS LSAQLSQLQK QLAAKEAKLR
DLEDSLARER DTSRRLLAEK EREMAEMRAR MQQQLDEYQE LLDIKLALDM EIHAYRKLLE
GEEERLRLSP SPTSQRSRGR ASSHSSQTQG TGSITKKRKL ESTESRSSFS QHARTSGRVA
VEEVDEDGKF VRLRNKSNED QSMGNWQIKR QNGDDPLLTY RFPPKFTLKA GQVVTIWAAG
AGATHSPPTD LVWKAQNTWG CGNSLRTALI NSTGEEVAMR KLVRSVTVVE DDEDEDGDDL
LHHHHVSGSR R
//
