ID A0A2K6S6V2_SAIBB Unreviewed; 1279 AA.
AC A0A2K6S6V2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Euchromatic histone lysine methyltransferase 1 {ECO:0000313|Ensembl:ENSSBOP00000003110.1};
GN Name=EHMT1 {ECO:0000313|Ensembl:ENSSBOP00000003110.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000003110.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000003110.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6S6V2; -.
DR STRING; 39432.ENSSBOP00000003110; -.
DR Ensembl; ENSSBOT00000017029.1; ENSSBOP00000003110.1; ENSSBOG00000013409.1.
DR GeneTree; ENSGT00940000156002; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0046974; F:histone H3K9 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:Ensembl.
DR GO; GO:0140718; P:facultative heterochromatin formation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10535; SET_EHMT1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038035; SET_EHMT1.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT REPEAT 753..785
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 786..818
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 819..843
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 853..885
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 919..951
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1041..1104
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1107..1224
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..410
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1279 AA; 139074 MW; 34084F2B76482A8D CRC64;
LSAAVPARGE PQQDCCVKTE LLGEETPMAA DEGSTEKQAG EAHLAADGET NGSCENSDAS
SHANAAKHTQ ESARANTQDG TSTLTRIAEN GLSERDSEAG KQNHVTTDDF VQTSIVGSNG
YILNKPALQA QPLRTTNTLA SSLPGHAAKT LPGGAGKGRT PSAFPQTPAA PPATLGEGSA
DAEDRKAPAS GTDVKVHRAR KTMPKSVVGL HAASKDPREV REARDHKEPK EEINKNISDF
GRQQLLPPFP SLHPSLPQNQ CYMATTKSQT ACLPFVLAAA VSRKKKRRMG TYSLVPKKKT
KVLKQRTVIE MFKSITHSTV GSKGEKDLGA SNLHVNGESL EMDSDEDDSE ELEEDDSHGA
EQAAAFPTED SRTSKESMSE VDRTQKMDGE SEEEQESADT GEEEEGGDES DLVMPSPSFH
VSWLPCGVWV GAAARAQGSE PYKSSSGSTE QTAPGDSTGY MEVSLDSLDL RVKGILSSQA
EGLANGPDVL ETDGLQEVPL CSCRMETPKS REITTLANSQ CMATESVDHE LGRCTNSVVK
YELMRPSNKA PLLVLCEDHR GRMVKHQCCP GCGYFCTAGN FMECQPESSI SHRFHKDCAS
RVNNASYCPH CGEESSKAKE VTIAKADTTS TVTPVPGQEK GSALEGRADT TTGSAAGPQL
SEDDKLQGPA SHAPEGFDPS GPAGLGRPTP GLSQGPGKET LESALIALDS EKPKKLRFHP
KQLYFSARQG ELQKVLLMLV DGIDPNFKME HQNKRSPLHA AAEAGHVDIC HMLVQAGANI
DTCSEDQRTP LMEAAENNHL EAVKYLIKAG ALVDPKDAEG STCLHLAAKK GHYEVVQYLL
SNGQMDVNCQ DDGGWTPMIW ATEYKHVDLV KLLLSKGSDI NIRDNEENIC LHWAAFSGCV
DIAEILLAAK CDLHAVNIHG DSPLHIAARE NRYDCVVLFL SRDSDVTLKN KEGETPLQCA
SLNSQVWSAL QMSKALQDSA PDRPAPVERT VSRDIARGYE RIPIPCVNAV DGEPCPSNYK
YVSQNCVTSP MNIDRNITHL QYCVCVDDCS SSNCMCGQLS MRCWYDKDGR LLPEFNMAEP
PLIFECNHAC SCWRNCRNRV VQNGLRARLQ LYRTRDMGWG VRSLQDIPLG TFVCEYVGEL
ISDSEADVRE EDSYLFDLDN KDGEVYCIDA RFYGNVSRFI NHHCEPNLVP VRVFMAHQDL
RFPRIAFFST RLIEAGEQLG FDYGERFWDI KGKLFSCRCG SPKCRHSSAA LAQRQASAAQ
EAQEDGLPDT SSAAAADPL
//
