ID A0A2K6SHC9_SAIBB Unreviewed; 331 AA.
AC A0A2K6SHC9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=GDNF family receptor alpha-2 {ECO:0000256|ARBA:ARBA00016726};
GN Name=GFRA2 {ECO:0000313|Ensembl:ENSSBOP00000006788.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000006788.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000006788.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC autophosphorylation and activation of the RET receptor. Also able to
CC mediate GDNF signaling through the RET tyrosine kinase receptor.
CC {ECO:0000256|ARBA:ARBA00025392}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR AlphaFoldDB; A0A2K6SHC9; -.
DR Ensembl; ENSSBOT00000023538.1; ENSSBOP00000006788.1; ENSSBOG00000020287.1.
DR GeneTree; ENSGT00940000156168; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003504; GDNF_rcpt_a2.
DR PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 2.
DR PRINTS; PR01318; GDNFRALPHA2.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 2.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..331
FT /note="GDNF family receptor alpha-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014328950"
FT DOMAIN 28..108
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 118..214
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 230..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 331 AA; 36337 MW; 5ECD9EA11D7AF1D8 CRC64;
MILANAFCLF FFLGTGADPV VSAKSNHCLD AAKACNLNDN CKKLRSSYIS ICNREISPTE
RCNRRKCHKA LRQFFDRVPS EFTYRMLFCS CQDLACAERR RQTILPSCSY EDKEKPNCLD
LRGVCRTDHL CRSRLADFHA NCRASHHTAT GCPADNYQAC LGSYAGMIGF DMTPNYVDSS
PTGIVVSPWC NCRGSGNMEE ECEKFLRDFT ENLCLRNAIQ AFGNGTDVNV SPKGPSFQAT
QAPRVEKTPS LPDDLSDSTS LGTSVITTCT SVQEQGLKAN SSKELSMCFT ELTTNIIPGS
NKVIKPNSGP SRARPSAALT VLSVLMLKLA L
//
