ID A0A2K6SHL1_SAIBB Unreviewed; 1676 AA.
AC A0A2K6SHL1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Polycystin 1 like 3, transient receptor potential channel interacting {ECO:0000313|Ensembl:ENSSBOP00000006875.1};
GN Name=PKD1L3 {ECO:0000313|Ensembl:ENSSBOP00000006875.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000006875.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000006875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR STRING; 39432.ENSSBOP00000006875; -.
DR Ensembl; ENSSBOT00000023627.1; ENSSBOP00000006875.1; ENSSBOG00000020403.1.
DR GeneTree; ENSGT00940000162813; -.
DR OMA; LYIRTSI; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR PANTHER; PTHR10877:SF136; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 3; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1676
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014435002"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1177..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1424..1443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1463..1480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1512..1532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1552..1573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1593..1621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..138
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 734..851
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 212..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 189926 MW; 7871EECE856F1F11 CRC64;
MFFKGRSWLW LYVRTSIILG SELNSPERGG QNNCYQLNSF HCSFEEAEHY CHAQGGFLAH
IRNQEVPDRI RDFLEEGKKW WIGRNVMPLK KHQDEKYPAD TAAYGDTKPS SCTYLSRNFS
QISFKGDKCS LGHYFICQTG GVQGRNLSSA TSASWVPVIL LPQCLKYWFL FSIGAAHLST
TCHHPPHAHL SKTLCHPISP FSSVLPKITA QATPVTSEPS SQPLPARTEP TSPASVTYAG
QSRTETASSS EEDAHPNSFT SHHPASLQNA SGQVIDEIVG NFSRAVDGLQ AHNKLQEACE
LLQKLTALTL RFSKPAQVHL INSLIYLSEQ FLRIPFQNNS SLGFKVPVTV CLFDSFNNVI
KAEEGSWQGS KHDPQQVEDM LEMSLVVLGN IGEAFLEQKQ PPESSVTLTS SIASLLLSRQ
NLSTLPLSSY MLGHPAPVRL GFPSASALKE LLNKHPGVNV QVTGLAFNPF KDLDNRNIVG
SIGSVLLSAN HKLLQVHDLM EDIEIMLWRN VSLETHPTSV NMSTDHFTIT VNVTSLEKSL
IVSIDPDSPL LMTLYLGFQY QPNCTHFHLN ITLPKDKVWQ KDEEYTWVLT PEHLQHGIGT
YYITAVLSES QEGAQQVSVV TAVTQCYYWD SHNRTWSSNG CQVGPQSTIL RTQCLCNHLT
FFASDFLVVP RTVNVEDTII LFLRVTSNPV GVSLLASLFG FYMITVVWAW RKDQADMQKV
KVTVLADNDP SAQFHYLIQV YTGYRRRAAT TAKVVITLYG SEGRSEPHHL CDPQKTVFER
GGLDVFLLTT HSSLGELHSL RLWHDNSGLS PSWYVTQVIV CDMAVKRKWH FLCNCWLAVD
LGDCELDRVF IPVSQRELSS FRHLFSSMIV EKFTQDYLWL SVATRHPWNL FTRVQRLSCC
MTLLLCNMVI SIMFWKINGT TGKRDEQMGT FAVAWSELLI SIHTALILFP INLVIGQLFP
LIQPRETVPL FPPIQVSCLL DASVESLSVT MVVEELRETV QFLLRRHTYL LSECEQLSWS
SCNITKLVEL LSSLLSSHLE GQGCHQAEHH WAHVVPENHH HFCCYLCRVL QRLKSHLGTL
GLTQGHQTCD LLAAASHLQK LQELLETHML PTEQEPFREV TSFAILSSEE GKRPISNGLS
KWLSSFCWLL LGLTSLASAF FTALYSLELN KDQATSWMIS IILSVLQNIL ISQPVKVVVF
TFVHSLMMSR VPRLHKEKEQ QTKRILALSA KCSSSVPGSR DKNNPIYVAP TMNSPTKHPE
RTLKKKTLFK LTGDILVQIF FLTLLMTTIY SAKNSNRFYL HQAIRRTFAH RFSEIKLLQD
FYPWANHILL PNLYGDYRGK NAVLELSHCK CGIQLIFQIP ATKTHEKVRK VSWLLLIRPY
LWRVQLYLFT QNGFSDIMRR NWSAFFTSVR LESFTSLQMS KKGFVWSVIS QVMYYLLICY
YAFIQGCRLK RQKWRFFTRK TNILDTSIIL ISFIILGLDM KSISLHKKNM ARYHHDRDRF
ISFYEAVKVN SATTHLVGFL VLLATVQLWN LLRHSPRLWV ISRTLSQAWD EVVGFLLIIL
ILLTGYAIAL WFFDMAETVL LLPSQVIALD PVLGTFLILT SVILMVLVVI NLFVSAILMA
FGKERKSLKR QVALIDTLLL KLSNLLGIRQ PQKTSSEQAA TTSMGIDSEV LEDELP
//
