ID A0A2K6SIQ0_SAIBB Unreviewed; 1324 AA.
AC A0A2K6SIQ0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX57 {ECO:0000313|Ensembl:ENSSBOP00000007256.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000007256.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000007256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR Ensembl; ENSSBOT00000024011.1; ENSSBOP00000007256.1; ENSSBOG00000020579.1.
DR GeneTree; ENSGT00940000156883; -.
DR OMA; PERVYVQ; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17985; DEXHc_DHX57; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF256; ATP-DEPENDENT RNA HELICASE DHX57-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 237..264
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 492..659
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 768..948
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT ZN_FING 237..264
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1324 AA; 148941 MW; 8F15625AD367F678 CRC64;
MSSSVRRKGK PGKGGGKGSS RGGRGGRSHA SKSHGSGSGG GGGGSGGGGG NRKASSRIWD
DGDDFCIFSE SRRPSRPNNS NTSKGEARPK WKPKAKVPLQ TLHMTSENQE KVKALLRDLQ
EQDADAGSEY GFSVERCQAV LRICDGDVGA SLEHLLTQCF SETFGERMKI SEAVNQISLD
ECVEQRQEEA FALRSICGEK FIERIENRVW TIGLELEYLT SRFRKSKQKE NTKNVQENSL
EICTFYLKGN CKFGSKCKFK HEVPPNQIVG RIERSVDDSH LNANEDASFL YELEIRFSKD
HKYPYQAPLV AFYSTNENLP LACRLHISEF LYDKALTFAE TSEPVVYSLI TLLEEESEIV
KLLTNTHHKY SVPPVNFLPV PSRTRINNPA CHKPVIPNNS FVSNQIPEVE KESESEESEE
DEGPAPVIVE NESYVNLKKK ISKRYDWQAK SVYAENGKIC KQFRMKQASR QFQSILQERQ
SLPAWEERET ILNLLRKHQV VVISGMTGCG KTTQIPQFIL DDSLNGPPEK VANIICTQPR
RISAISVAER VAKERAERVG LTVGYQIRLE SVKSSATRLL YCTTGVLLRR LEGDTALQGV
SHIIVDEVHE RTEESDFLLL VLKDIVSQRP TLQVILMSAT LNAELFSEYF NSCPVITIPG
RTFPVDQFFL EDAIAVTRYV LQDGSPYMRS MKQISKEKLK ARRNRTAFEE VEEDLRLSLH
LQDQDSVKDA VPDQQLDFKQ LLARYKGVSK SVIKTMSIMD FEKVNLELIE ALLEWIVDGK
HSYPPGAILV FLPGLAEIKM LYEQLQSNSL FNNRRSNRCV IHPLHSSLSS EEQQAVFVKP
PAGVTKIIIS TNIAETSITI DDVVYVIDSG KMKEKRYDAS KGMESLEDTF VSQANALQRK
GRAGRVASGV CFHLFTSHHY NHQLLKQQLP EIQRVPLEQL CLRIKILEMF NAHNLQSVFS
RLIEPPHADS LRASKIRLRD LGALTPDEKL TPLGYHLASL PVDVRIGKLM LFGSIFRCLD
PALTIAASLA FKSPFVSPWD KKEEANQKKL EFAFANSDYL ALLRAYKGWQ LSTKEGVRAS
YNYCRQNFLS GRVLQEMASL KRQFTELLSD IGFAREGLRA REIEKRAQGG DGVLDATGEE
ANSNAENPKL ILAMLCAALY PNVVQVKSPE EKFQKTSTGA VRMQPKSAEL KFVTKNDGYV
HIHPSSVNYQ VRQFDSPYLL YHEKIKTSRV FIRDCSMVSV YPLVLFGGGQ VNVQLQRGEF
VVSLDDGWIR FVAASHQVAE LVKELRCELD QLLQDKIKNP NIDLCTCPRG SRIISTIVKL
VTTQ
//
